POU2F3

Protein-coding gene in the species Homo sapiens
POU2F3
Identifiers
AliasesPOU2F3, Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a, POU class 2 homeobox 3
External IDsOMIM: 607394; MGI: 102565; HomoloGene: 7898; GeneCards: POU2F3; OMA:POU2F3 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for POU2F3
Genomic location for POU2F3
Band11q23.3Start120,236,640 bp[1]
End120,319,945 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for POU2F3
Genomic location for POU2F3
Band9 A5.1|9 24.21 cMStart43,035,234 bp[2]
End43,121,666 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • skin of leg

  • skin of thigh

  • skin of hip

  • nipple

  • skin of arm

  • vulva

  • palpebral conjunctiva

  • human penis

  • mucosa of transverse colon
Top expressed in
  • lip

  • gastrula

  • Ileal epithelium

  • urethra

  • zygote

  • male urethra

  • zone of skin

  • skin of external ear

  • skin of back

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • regulation of transcription by RNA polymerase II
  • epidermis development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25833

18988

Ensembl

ENSG00000137709

ENSMUSG00000032015

UniProt

Q9UKI9

P31362

RefSeq (mRNA)

NM_001244682
NM_014352

NM_011139

RefSeq (protein)

NP_001231611
NP_055167

n/a

Location (UCSC)Chr 11: 120.24 – 120.32 MbChr 9: 43.04 – 43.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137709 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032015 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hildesheim J, Foster RA, Chamberlin ME, Vogel JC (Oct 1999). "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor". J Biol Chem. 274 (37): 26399–406. doi:10.1074/jbc.274.37.26399. PMID 10473598.
  6. ^ "Entrez Gene: POU2F3 POU domain, class 2, transcription factor 3".

Further reading

  • Goldsborough A, et al. (1990). "Cloning and sequencing of POU-boxes expressed in mouse testis". Nucleic Acids Res. 18 (6): 1634. doi:10.1093/nar/18.6.1634. PMC 330540. PMID 1970171.
  • Goldsborough AS, Healy LE, Copeland NG, et al. (1993). "Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11". Nucleic Acids Res. 21 (1): 127–34. doi:10.1093/nar/21.1.127. PMC 309074. PMID 8441607.
  • Sugihara TM, Kudryavtseva EI, Kumar V, et al. (2001). "The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300". J. Biol. Chem. 276 (35): 33036–44. doi:10.1074/jbc.M103000200. PMID 11429405.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. hdl:1887/50054. PMID 12624109.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Enomoto Y, Enomoto K, Kitamura T, Kanda T (2004). "Keratinocyte-specific POU transcription factor hSkn-1a represses the growth of cervical cancer cell lines". Oncogene. 23 (29): 5014–22. doi:10.1038/sj.onc.1207653. PMID 15077167.
  • Jiménez-Mateo O, Rodríguez-Torres A, Avila S, Castrillo JL (2006). "The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression". Placenta. 27 (4–5): 357–66. doi:10.1016/j.placenta.2005.03.011. PMID 16005513.
  • Zhang Z, Huettner PC, Nguyen L, et al. (2006). "Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer". Oncogene. 25 (39): 5436–45. doi:10.1038/sj.onc.1209530. PMID 16607278.
  • Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation". J. Invest. Dermatol. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013.
  • v
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  • e
  • 1pou: THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN
    1pou: THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN


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