PPP1R17

Protein-coding gene in the species Homo sapiens

PPP1R17
Identifiers
AliasesPPP1R17, C7orf16, GSBS, protein phosphatase 1 regulatory subunit 17
External IDsOMIM: 604088; MGI: 1333876; HomoloGene: 4849; GeneCards: PPP1R17; OMA:PPP1R17 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for PPP1R17
Genomic location for PPP1R17
Band7p14.3Start31,687,215 bp[1]
End31,708,455 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for PPP1R17
Genomic location for PPP1R17
Band6 B3|6 27.65 cMStart55,994,482 bp[2]
End56,009,674 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • lateral nuclear group of thalamus

  • cerebellar vermis

  • right hemisphere of cerebellum

  • ventricular zone

  • testicle

  • hypothalamus

  • pons

  • anterior pituitary

  • granulocyte
Top expressed in
  • lobe of cerebellum

  • cerebellar vermis

  • trigeminal ganglion

  • suprachiasmatic nucleus

  • dorsomedial hypothalamic nucleus

  • endocardial cushion

  • superior cervical ganglion

  • glossopharyngeal ganglion

  • atrioventricular junction

  • Epithelium of choroid plexus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein phosphatase inhibitor activity
  • protein serine/threonine phosphatase inhibitor activity
  • phosphatase inhibitor activity
Cellular component
  • cellular component
  • nucleoplasm
Biological process
  • regulation of phosphatase activity
  • central nervous system development
  • intracellular signal transduction
  • negative regulation of catalytic activity
  • negative regulation of phosphoprotein phosphatase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10842

19051

Ensembl

ENSG00000106341

ENSMUSG00000002930

UniProt

O96001

Q9Z2E4

RefSeq (mRNA)

NM_001145123
NM_006658

NM_011153

RefSeq (protein)

NP_001138595
NP_006649

NP_035283

Location (UCSC)Chr 7: 31.69 – 31.71 MbChr 6: 55.99 – 56.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase 1 regulatory subunit 17 is a protein that in humans is encoded by the PPP1R17 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106341 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002930 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M (Mar 1999). "Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2467–72. Bibcode:1999PNAS...96.2467E. doi:10.1073/pnas.96.5.2467. PMC 26808. PMID 10051666.
  6. ^ Hall KU, Collins SP, Gamm DM, Massa E, DePaoli-Roach AA, Uhler MD (Feb 1999). "Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 274 (6): 3485–95. doi:10.1074/jbc.274.6.3485. PMID 9920894.
  7. ^ "Entrez Gene: C7orf16 chromosome 7 open reading frame 16".

Further reading

  • Ono S, Ezura Y, Emi M, Fujita Y, Takada D, Sato K, Ishigami T, Umemura S, Takahashi K, Kamimura K, Bujo H, Saito Y (2003). "A promoter SNP (-1323T>C) in G-substrate gene (GSBS) correlates with hypercholesterolemia". Journal of Human Genetics. 48 (9): 447–50. doi:10.1007/s10038-003-0055-x. PMID 12955585.
  • Sanger Centre T, Washington University Genome Sequencing Cente T (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.


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