PRICKLE4

Protein-coding gene in the species Homo sapiens
PRICKLE4
Identifiers
AliasesPRICKLE4, C6orf49, OBTP, OEBT, TOMM6, prickle planar cell polarity protein 4
External IDsOMIM: 611389; MGI: 2685785; HomoloGene: 22752; GeneCards: PRICKLE4; OMA:PRICKLE4 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PRICKLE4
Genomic location for PRICKLE4
Band6p21.1Start41,780,782 bp[1]
End41,787,452 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for PRICKLE4
Genomic location for PRICKLE4
Band17|17 CStart47,999,442 bp[2]
End48,005,661 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • right lobe of thyroid gland

  • right hemisphere of cerebellum

  • spleen

  • left lobe of thyroid gland

  • apex of heart

  • right uterine tube

  • body of uterus

  • myometrium
Top expressed in
  • white adipose tissue

  • muscle tissue

  • proximal tubule

  • muscle of thigh

  • quadriceps femoris muscle

  • skeletal muscle tissue

  • embryo

  • urinary bladder

  • striatum of neuraxis

  • spermatocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • metal ion binding
  • molecular function
  • actin binding
  • muscle alpha-actinin binding
Cellular component
  • nucleus
  • stress fiber
  • Z discdkac
  • filamentous actin
Biological process
  • biological process
  • heart development
  • actin cytoskeleton organization
  • muscle structure development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29964

381104

Ensembl

ENSG00000278224

ENSMUSG00000096549

UniProt

Q2TBC4

n/a

RefSeq (mRNA)

NM_013397
NM_017601

NM_001290337

RefSeq (protein)

NP_037529

n/a

Location (UCSC)Chr 6: 41.78 – 41.79 MbChr 17: 48 – 48.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prickle-like protein 4 is a protein that in humans is encoded by the PRICKLE4 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000278224 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096549 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Teufel A, Weinmann A, Galle PR, Lohse AW (Mar 2005). "Characterization of OEBT, a LIM protein". International Journal of Molecular Medicine. 15 (3): 513–8. doi:10.3892/ijmm.15.3.513. PMID 15702247.
  6. ^ "Entrez Gene: C6orf49 chromosome 6 open reading frame 49".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Chassin D, Bénifla JL, Delattre C, Fernandez H, Ginisty D, Janneau JL, Prade M, Contesso G, Caillou B, Tournaire M (Oct 1994). "Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts". Cancer Research. 54 (19): 5217–23. PMID 7923143.


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