PRUNE2

Protein-coding gene in the species Homo sapiens

PRUNE2
Identifiers
AliasesPRUNE2, A214N16.3, BMCC1, BNIPXL, C9orf65, KIAA0367, bA214N16.3, prune homolog 2 (Drosophila), prune homolog 2, prune homolog 2 with BCH domain
External IDsOMIM: 610691; MGI: 1925004; HomoloGene: 18939; GeneCards: PRUNE2; OMA:PRUNE2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for PRUNE2
Genomic location for PRUNE2
Band9q21.2Start76,611,376 bp[1]
End76,906,114 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for PRUNE2
Genomic location for PRUNE2
Band19|19 BStart16,933,482 bp[2]
End17,201,296 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spinal ganglia

  • decidua

  • gastric mucosa

  • Descending thoracic aorta

  • endothelial cell

  • cerebellar vermis

  • popliteal artery

  • tibial arteries

  • ascending aorta

  • corpus callosum
Top expressed in
  • facial motor nucleus

  • cerebellar cortex

  • lobe of cerebellum

  • medial dorsal nucleus

  • spinal ganglia

  • cerebellar vermis

  • lumbar spinal ganglion

  • trigeminal ganglion

  • lateral geniculate nucleus

  • medial geniculate nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • pyrophosphatase activity
  • metal ion binding
  • exopolyphosphatase activity
Cellular component
  • cytoplasm
Biological process
  • apoptotic process
  • polyphosphate catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

158471

353211

Ensembl

ENSG00000106772

ENSMUSG00000039126

UniProt

Q8WUY3

Q52KR3

RefSeq (mRNA)
NM_001308047
NM_001308048
NM_001308049
NM_001308050
NM_001308051

NM_015225
NM_138818
NM_001330680

NM_181348

RefSeq (protein)
NP_001294976
NP_001294977
NP_001294978
NP_001294979
NP_001294980

NP_001317609
NP_056040
NP_001294976.1
NP_001294977.1

NP_851993

Location (UCSC)Chr 9: 76.61 – 76.91 MbChr 19: 16.93 – 17.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein prune homolog 2 is a protein that in humans is encoded by the PRUNE2 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106772 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039126 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Machida T, Fujita T, Ooo ML, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A (Mar 2006). "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas". Oncogene. 25 (13): 1931–42. doi:10.1038/sj.onc.1209225. PMID 16288218. S2CID 19976655.
  6. ^ "Entrez Gene: PRUNE2 prune homolog 2 (Drosophila)".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Price ND, Trent J, El-Naggar AK, et al. (2007). "Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3414–9. Bibcode:2007PNAS..104.3414P. doi:10.1073/pnas.0611373104. PMC 1805517. PMID 17360660.


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