PUM3

Protein-coding gene in the species Homo sapiens

PUM3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4WZR, 4WZW

Identifiers
AliasesPUM3, D19Bwg1357e, 1110069H02Rik, AA675048, Kiaa0020, HA-8, HLA-HA8, PEN, PUF-A, PUF6, XTP5, KIAA0020, pumilio RNA binding family member 3
External IDsOMIM: 609960; MGI: 106253; HomoloGene: 5762; GeneCards: PUM3; OMA:PUM3 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for PUM3
Genomic location for PUM3
Band9p24.2Start2,720,469 bp[1]
End2,844,095 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for PUM3
Genomic location for PUM3
Band19 C1|19 21.96 cMStart27,366,098 bp[2]
End27,407,225 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • mucosa of transverse colon

  • mucosa of esophagus

  • gonad

  • testicle

  • olfactory zone of nasal mucosa

  • left ovary

  • minor salivary glands

  • body of pancreas

  • right ovary
Top expressed in
  • Paneth cell

  • renal corpuscle

  • endothelial cell of lymphatic vessel

  • epiblast

  • primitive streak

  • medullary collecting duct

  • internal carotid artery

  • ureter

  • abdominal wall

  • hair follicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • mRNA binding
  • RNA binding
Cellular component
  • endoplasmic reticulum
  • nucleus
  • nucleoplasm
  • nucleolus
  • chromosome
Biological process
  • regulation of protein ADP-ribosylation
  • regulation of translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9933

52874

Ensembl

ENSG00000080608

ENSMUSG00000041360

UniProt

Q15397

Q8BKS9

RefSeq (mRNA)

NM_001031691
NM_014878

NM_177474

RefSeq (protein)

NP_055693

NP_803425

Location (UCSC)Chr 9: 2.72 – 2.84 MbChr 19: 27.37 – 27.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

pumilio RNA binding family member 3 (previously KIAA0020[5]) is a protein that in humans is encoded by the PUM3 gene.[6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080608 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041360 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "PUM3 Symbol Report | HUGO Gene Nomenclature Committee". www.genenames.org. Retrieved 2017-01-24.
  6. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Research. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  7. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Research. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
  8. ^ "Entrez Gene: KIAA0020 KIAA0020".

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hoja MR, Wahlestedt C, Höög C (August 2000). "A visual intracellular classification strategy for uncharacterized human proteins". Experimental Cell Research. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
  • Brickner AG, Warren EH, Caldwell JA, Akatsuka Y, Golovina TN, Zarling AL, Shabanowitz J, Eisenlohr LC, Hunt DF, Engelhard VH, Riddell SR (January 2001). "The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing". The Journal of Experimental Medicine. 193 (2): 195–206. doi:10.1084/jem.193.2.195. PMC 2193344. PMID 11148223.
  • Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Warren EH, Otterud BE, Linterman RW, Brickner AG, Engelhard VH, Leppert MF, Martin PJ, Riddell SR (April 2002). "Feasibility of using genetic linkage analysis to identify the genes encoding T cell-defined minor histocompatibility antigens". Tissue Antigens. 59 (4): 293–303. doi:10.1034/j.1399-0039.2002.590407.x. PMID 12135428.
  • Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
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