QRFP

Protein-coding gene in the species Homo sapiens
QRFP
Identifiers
AliasesQRFP, 26RFa, P518, pyroglutamylated RFamide peptide
External IDsOMIM: 609795; MGI: 3630329; HomoloGene: 52341; GeneCards: QRFP; OMA:QRFP - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for QRFP
Genomic location for QRFP
Band9q34.12Start130,892,707 bp[1]
End130,896,812 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for QRFP
Genomic location for QRFP
Band2|2 BStart31,696,178 bp[2]
End31,700,592 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • mucosa of transverse colon

  • muscle layer of sigmoid colon

  • stromal cell of endometrium

  • popliteal artery

  • tibial arteries

  • sural nerve

  • left coronary artery

  • Descending thoracic aorta
Top expressed in
  • embryo

  • islet of Langerhans

  • white adipose tissue

  • spermatocyte

  • adrenal gland

  • duodenum

  • lip

  • spleen

  • hypothalamus

  • uterus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • orexigenic neuropeptide QRFP receptor binding
  • neuropeptide hormone activity
Cellular component
  • extracellular region
  • cellular component
Biological process
  • grooming behavior
  • positive regulation of blood pressure
  • neuropeptide signaling pathway
  • regulation of feeding behavior
  • locomotory behavior
  • regulation of signaling receptor activity
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

347148

227717

Ensembl

ENSG00000188710

ENSMUSG00000043102

UniProt

P83859

Q8CE23

RefSeq (mRNA)

NM_198180

NM_183424

RefSeq (protein)

NP_937823

NP_906269

Location (UCSC)Chr 9: 130.89 – 130.9 MbChr 2: 31.7 – 31.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.[5]

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[6] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188710 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043102 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide".
  6. ^ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
  7. ^ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.
  • "Peptide P518 Receptor". IUPHAR/BPS Guide to PHARMACOLOGY.

Further reading

  • Bruzzone F, Lectez B, Tollemer H, et al. (2007). "Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord". J. Neurochem. 99 (2): 616–27. doi:10.1111/j.1471-4159.2006.04090.x. PMID 16899066. S2CID 41427365.
  • Chartrel N, Bruzzone F, Dujardin C, et al. (2006). "Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals". Ann. N. Y. Acad. Sci. 1040 (1): 80–3. Bibcode:2005NYASA1040...80C. doi:10.1196/annals.1327.009. PMID 15891009. S2CID 21012765.
  • Thuau R, Guilhaudis L, Ségalas-Milazzo I, et al. (2005). "Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity". Peptides. 26 (5): 779–89. doi:10.1016/j.peptides.2005.01.006. PMID 15808908. S2CID 24088690.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chartrel N, Dujardin C, Anouar Y, et al. (2004). "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 15247–52. Bibcode:2003PNAS..10015247C. doi:10.1073/pnas.2434676100. PMC 299975. PMID 14657341.
  • Fukusumi S, Yoshida H, Fujii R, et al. (2004). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.
  • Jiang Y, Luo L, Gustafson EL, et al. (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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