RAB13

Protein-coding gene in the species Homo sapiens
RAB13
Identifiers
AliasesRAB13, GIG4, member RAS oncogene family
External IDsOMIM: 602672; MGI: 1927232; HomoloGene: 113882; GeneCards: RAB13; OMA:RAB13 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RAB13
Genomic location for RAB13
Band1q21.3Start153,981,617 bp[1]
End153,986,358 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for RAB13
Genomic location for RAB13
Band3 F1|3 39.21 cMStart90,121,002 bp[2]
End90,133,692 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • gastric mucosa

  • Descending thoracic aorta

  • left coronary artery

  • right adrenal cortex

  • left adrenal cortex

  • fundus

  • prostate

  • human kidney

  • subcutaneous adipose tissue
Top expressed in
  • yolk sac

  • molar

  • lens

  • otic vesicle

  • utricle

  • efferent ductule

  • external carotid artery

  • tail of embryo

  • epithelium of small intestine

  • epiblast
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • protein kinase A catalytic subunit binding
  • GTP binding
  • protein binding
  • GTPase activity
Cellular component
  • recycling endosome
  • endosome
  • Golgi apparatus
  • cell projection
  • lateral plasma membrane
  • membrane
  • cell-cell junction
  • bicellular tight junction
  • insulin-responsive compartment
  • plasma membrane
  • endocytic vesicle
  • recycling endosome membrane
  • trans-Golgi network
  • neuron projection
  • extracellular exosome
  • cytoplasmic vesicle
  • lamellipodium
  • cytosol
  • cell junction
  • cytoplasmic vesicle membrane
Biological process
  • trans-Golgi network to recycling endosome transport
  • establishment of Sertoli cell barrier
  • protein localization to cell leading edge
  • endosomal transport
  • bicellular tight junction assembly
  • endothelial cell chemotaxis
  • endocytic recycling
  • cellular response to insulin stimulus
  • protein kinase A signaling
  • protein transport
  • neuron projection development
  • cortical actin cytoskeleton organization
  • post-translational protein modification
  • transport
  • protein localization to plasma membrane
  • intracellular protein transport
  • Rab protein signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5872

68328

Ensembl

ENSG00000143545

ENSMUSG00000027935

UniProt

P51153

Q9DD03

RefSeq (mRNA)

NM_001272038
NM_002870

NM_001293741
NM_026677

RefSeq (protein)

NP_001258967
NP_002861

NP_001280670
NP_080953

Location (UCSC)Chr 1: 153.98 – 153.99 MbChr 3: 90.12 – 90.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-13 is a protein that in humans is encoded by the RAB13 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143545 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027935 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zahraoui A, Joberty G, Arpin M, Fontaine JJ, Hellio R, Tavitian A, Louvard D (Feb 1994). "A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells". J Cell Biol. 124 (1–2): 101–15. doi:10.1083/jcb.124.1.101. PMC 2119893. PMID 8294494.
  6. ^ "Entrez Gene: RAB13 RAB13, member RAS oncogene family".

Further reading

  • Joberty G, Tavitian A, Zahraoui A (1993). "Isoprenylation of Rab proteins possessing a C-terminal CaaX motif". FEBS Lett. 330 (3): 323–8. doi:10.1016/0014-5793(93)80897-4. PMID 8375503. S2CID 29047580.
  • Leek JP, Hamlin PJ, Wilton J, Lench NJ (1998). "Assignment of the Rab13 gene (RAB13) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 210–1. doi:10.1159/000134724. PMID 9605854.
  • Marzesco AM, Galli T, Louvard D, Zahraoui A (1998). "The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes". J. Biol. Chem. 273 (35): 22340–5. doi:10.1074/jbc.273.35.22340. PMID 9712853.
  • Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381. S2CID 23540699.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Morimoto S, Nishimura N, Terai T, et al. (2005). "Rab13 mediates the continuous endocytic recycling of occludin to the cell surface". J. Biol. Chem. 280 (3): 2220–8. doi:10.1074/jbc.M406906200. PMID 15528189.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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