RAB7B

Protein-coding gene in the species Homo sapiens
RAB7B
Identifiers
AliasesRAB7B, RAB7, member RAS oncogene family
External IDsMGI: 2442295; HomoloGene: 64833; GeneCards: RAB7B; OMA:RAB7B - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RAB7B
Genomic location for RAB7B
Band1q32.1Start205,976,740 bp[1]
End206,003,461 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for RAB7B
Genomic location for RAB7B
Band1|1 E4Start131,616,433 bp[2]
End131,643,177 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of arm

  • skin of abdomen

  • gingival epithelium

  • skin of leg

  • skin of thigh

  • mucosa of esophagus

  • gallbladder

  • skin of hip

  • right coronary artery

  • vagina
Top expressed in
  • stroma of bone marrow

  • lip

  • skin of back

  • calvaria

  • epidermis

  • esophagus

  • skin of abdomen

  • belly cord

  • cornea

  • ankle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • GTPase activity
Cellular component
  • endosome
  • late endosome
  • Golgi apparatus
  • trans-Golgi network
  • lysosome
  • phagocytic vesicle membrane
  • phagocytic vesicle
  • membrane
  • cytoplasmic vesicle
  • late endosome membrane
  • vacuolar membrane
Biological process
  • protein transport
  • negative regulation of toll-like receptor 9 signaling pathway
  • late endosome to Golgi transport
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of megakaryocyte differentiation
  • negative regulation of toll-like receptor 4 signaling pathway
  • positive regulation of interleukin-6 production
  • cellular response to interferon-gamma
  • intracellular protein transport
  • endosome to lysosome transport
  • Rab protein signal transduction
  • phagosome-lysosome fusion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

338382

226421

Ensembl

ENSG00000276600

ENSMUSG00000052688

UniProt

Q96AH8

Q8VEA8

RefSeq (mRNA)

NM_001164522
NM_001304839
NM_177403

NM_145509
NM_001311096

RefSeq (protein)

NP_001157994
NP_001291768
NP_796377

NP_001298025
NP_663484

Location (UCSC)Chr 1: 205.98 – 206 MbChr 1: 131.62 – 131.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.[5]

Function

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.[6] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000276600 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052688 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yang M, Chen T, Han C, Li N, Wan T, Cao X (June 2004). "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 318 (3): 792–9. doi:10.1016/j.bbrc.2004.04.115. PMID 15144907.
  6. ^ a b Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X (August 2007). "Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4". Blood. 110 (3): 962–71. doi:10.1182/blood-2007-01-066027. PMID 17395780. S2CID 28664736.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


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