RABGAP1

Protein-coding gene in the species Homo sapiens
RABGAP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4NC6

Identifiers
AliasesRABGAP1, GAPCENA, TBC1D11, RAB GTPase activating protein 1
External IDsOMIM: 615882; MGI: 2385139; HomoloGene: 49301; GeneCards: RABGAP1; OMA:RABGAP1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for RABGAP1
Genomic location for RABGAP1
Band9q33.2-q33.3Start122,940,833 bp[1]
End123,104,866 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for RABGAP1
Genomic location for RABGAP1
Band2|2 BStart37,333,291 bp[2]
End37,456,466 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • middle temporal gyrus

  • olfactory bulb

  • internal globus pallidus

  • optic nerve

  • amniotic fluid

  • endothelial cell

  • tail of epididymis

  • Brodmann area 23

  • saphenous vein
Top expressed in
  • genital tubercle

  • tail of embryo

  • pineal gland

  • zygote

  • superior cervical ganglion

  • arcuate nucleus

  • paraventricular nucleus of hypothalamus

  • median eminence

  • dorsomedial hypothalamic nucleus

  • medullary collecting duct
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • tubulin binding
  • protein binding
  • GTPase activator activity
Cellular component
  • cytoplasm
  • cytosol
  • centrosome
  • cytoskeleton
  • microtubule associated complex
  • microtubule organizing center
  • endomembrane system
Biological process
  • regulation of cilium assembly
  • cell cycle
  • positive regulation of GTPase activity
  • activation of GTPase activity
  • regulation of vesicle fusion
  • intracellular protein transport
  • regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23637

227800

Ensembl

ENSG00000011454

ENSMUSG00000035437

UniProt

Q9Y3P9

A2AWA9

RefSeq (mRNA)

NM_012197

NM_001033960
NM_146121
NM_001362956
NM_001362957
NM_001362958

RefSeq (protein)

NP_036329

NP_001029132
NP_666233
NP_001349885
NP_001349886
NP_001349887

Location (UCSC)Chr 9: 122.94 – 123.1 MbChr 2: 37.33 – 37.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAB GTPase activating protein 1 is a protein in humans that is encoded by the RABGAP1 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011454 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035437 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RAB GTPase activating protein 1".

Further reading

  • Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N (February 2007). "Identification of the ligands of protein interaction domains through a functional approach". Molecular & Cellular Proteomics. 6 (2): 333–45. doi:10.1074/mcp.M600289-MCP200. PMID 17124247.
  • Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Molecular Biology of the Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.
  • Ishibashi K, Kanno E, Itoh T, Fukuda M (January 2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes to Cells. 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID 19077034. S2CID 26454981.
  • Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (August 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID 10893188.
  • Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B (April 1999). "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome". The EMBO Journal. 18 (7): 1772–82. doi:10.1093/emboj/18.7.1772. PMC 1171263. PMID 10202141.
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