Protein-coding gene in the species Homo sapiens
RAI2 |
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Identifiers |
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Aliases | RAI2, retinoic acid induced 2 |
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External IDs | OMIM: 300217; MGI: 1344378; HomoloGene: 11034; GeneCards: RAI2; OMA:RAI2 - orthologs |
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Gene location (Human) |
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| Chr. | X chromosome (human)[1] |
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| Band | Xp22.13 | Start | 17,800,049 bp[1] |
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End | 17,861,337 bp[1] |
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Gene location (Mouse) |
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| Chr. | X chromosome (mouse)[2] |
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| Band | X|X F4 | Start | 160,500,065 bp[2] |
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End | 160,562,492 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - left uterine tube
- urethra
- right lung
- canal of the cervix
- body of uterus
- saphenous vein
- gastric mucosa
- left ovary
- vena cava
- decidua
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| Top expressed in | - myocardium of ventricle
- intercostal muscle
- cumulus cell
- supraoptic nucleus
- pineal gland
- aortic valve
- muscle of thigh
- islet of Langerhans
- Rostral migratory stream
- ganglionic eminence
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - protein binding
- molecular function
| Cellular component | | Biological process | - embryo development ending in birth or egg hatching
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001172732 NM_001172739 NM_001172743 NM_021785 |
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RefSeq (protein) | NP_001166203 NP_001166210 NP_001166214 NP_068557 NP_001166210.1
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NP_001166214.1 NP_068557.3 |
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Location (UCSC) | Chr X: 17.8 – 17.86 Mb | Chr X: 160.5 – 160.56 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Retinoic acid-induced protein 2 is a protein that in humans is encoded by the RAI2 gene.[5][6][7]
Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this intronless, retinoic acid-induced gene has not yet been determined; however, it has been suggested to play a role in development. Localization of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000131831 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043518 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Walpole SM, Hiriyana KT, Nicolaou A, Bingham EL, Durham J, Vaudin M, Ross MT, Yates JR, Sieving PA, Trump D (May 1999). "Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22". Genomics. 55 (3): 275–83. doi:10.1006/geno.1998.5667. PMID 10049581.
- ^ Walpole SM, Ronce N, Grayson C, Dessay B, Yates JR, Trump D, Toutain A (Jul 1999). "Exclusion of RAI2 as the causative gene for Nance-Horan syndrome". Hum Genet. 104 (5): 410–1. doi:10.1007/s004390050976. PMID 10394933. S2CID 5675053.
- ^ a b "Entrez Gene: RAI2 retinoic acid induced 2".
Further reading
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.