RASAL2

Protein-coding gene in the species Homo sapiens

RASAL2
Identifiers
AliasesRASAL2, NGAP, RAS protein activator like 2
External IDsOMIM: 606136; MGI: 2443881; HomoloGene: 35217; GeneCards: RASAL2; OMA:RASAL2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RASAL2
Genomic location for RASAL2
Band1q25.2Start178,094,104 bp[1]
End178,484,147 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for RASAL2
Genomic location for RASAL2
Band1|1 H1Start156,962,752 bp[2]
End157,240,165 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • amniotic fluid

  • right ventricle

  • oral cavity

  • middle temporal gyrus

  • saphenous vein

  • sural nerve

  • Brodmann area 23

  • mucosa of paranasal sinus

  • tendon of biceps brachii
Top expressed in
  • sciatic nerve

  • utricle

  • primary motor cortex

  • cingulate gyrus

  • trigeminal ganglion

  • lateral septal nucleus

  • piriform cortex

  • temporal lobe

  • anterior amygdaloid area

  • prefrontal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • GTPase activator activity
Cellular component
  • cytoplasm
  • cytosol
  • intrinsic component of the cytoplasmic side of the plasma membrane
Biological process
  • negative regulation of Ras protein signal transduction
  • regulation of GTPase activity
  • signal transduction
  • MAPK cascade
  • positive regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9462

226525

Ensembl

ENSG00000075391

ENSMUSG00000070565

UniProt

Q9UJF2

n/a

RefSeq (mRNA)

NM_004841
NM_170692

NM_177644
NM_001401202

RefSeq (protein)

NP_004832
NP_733793

n/a

Location (UCSC)Chr 1: 178.09 – 178.48 MbChr 1: 156.96 – 157.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene.[5][6]

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075391 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070565 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Noto S, Maeda T, Hattori S, Inazawa J, Imamura M, Asaka M, Hatakeyama M (Jan 1999). "A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25". FEBS Lett. 441 (1): 127–31. doi:10.1016/S0014-5793(98)01530-0. PMID 9877179.
  6. ^ a b "Entrez Gene: RASAL2 RAS protein activator like 2".

Further reading

  • Maekawa M, Nakamura S, Hattori S (1993). "Purification of a novel ras GTPase-activating protein from rat brain". J. Biol. Chem. 268 (30): 22948–52. doi:10.1016/S0021-9258(18)41618-3. PMID 8226805.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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