Protein-coding gene in the species Homo sapiens
| RASGRF2 |
|---|
|
| Identifiers |
|---|
| Aliases | RASGRF2, GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2 |
|---|
| External IDs | OMIM: 606614; MGI: 109137; HomoloGene: 2169; GeneCards: RASGRF2; OMA:RASGRF2 - orthologs |
|---|
| Gene location (Human) |
|---|
 | | Chr. | Chromosome 5 (human)[1] |
|---|
| | Band | 5q14.1 | Start | 80,960,363 bp[1] |
|---|
| End | 81,230,162 bp[1] |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 13 (mouse)[2] |
|---|
| | Band | 13 C3|13 47.43 cM | Start | 92,028,519 bp[2] |
|---|
| End | 92,268,164 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - middle temporal gyrus
- Brodmann area 23
- endothelial cell
- sural nerve
- Brodmann area 46
- prefrontal cortex
- corpus callosum
- superior frontal gyrus
- C1 segment
- occipital lobe
|
| | Top expressed in | - ventromedial nucleus
- olfactory tubercle
- neural layer of retina
- arcuate nucleus
- paraventricular nucleus of hypothalamus
- dorsomedial hypothalamic nucleus
- substantia nigra
- superior frontal gyrus
- dentate gyrus of hippocampal formation granule cell
- ventral tegmental area
|
| | More reference expression data |
|
|---|
| BioGPS | |
|---|
|
| Gene ontology |
|---|
| Molecular function | - calmodulin binding
- guanyl-nucleotide exchange factor activity
| | Cellular component | - cytoplasm
- cytosol
- endoplasmic reticulum membrane
- membrane
- plasma membrane
- endoplasmic reticulum
| | Biological process | - regulation of Ras protein signal transduction
- MAPK cascade
- positive regulation of apoptotic process
- regulation of Rho protein signal transduction
- regulation of small GTPase mediated signal transduction
- small GTPase mediated signal transduction
- response to endoplasmic reticulum stress
- G protein-coupled receptor signaling pathway
| | Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | | |
|---|
| RefSeq (protein) | | |
|---|
| Location (UCSC) | Chr 5: 80.96 – 81.23 Mb | Chr 13: 92.03 – 92.27 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.[5]
RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM][5]
Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000113319 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021708 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2".
- ^ "Binge Drinking Gene: RASGRF-2 Helps Explain Teenage Alcohol Abuse, Scientists Say". Huffington Post. 3 December 2012.
Further reading
- Fam NP, Zhang LJ, Rommens JM, et al. (1997). "Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene". Genomics. 39 (1): 118–20. doi:10.1006/geno.1996.4484. PMID 9027497.
- Fam NP, Fan WT, Wang Z, et al. (1997). "Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras". Mol. Cell. Biol. 17 (3): 1396–406. doi:10.1128/mcb.17.3.1396. PMC 231864. PMID 9032266.
- Fan WT, Koch CA, de Hoog CL, et al. (1998). "The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways". Curr. Biol. 8 (16): 935–8. Bibcode:1998CBio....8..935F. doi:10.1016/S0960-9822(07)00376-4. PMID 9707409. S2CID 8904502.
- Anborgh PH, Qian X, Papageorge AG, et al. (1999). "Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf". Mol. Cell. Biol. 19 (7): 4611–22. doi:10.1128/mcb.19.7.4611. PMC 84259. PMID 10373510.
- Lutchman M, Kim AC, Cheng L, et al. (2002). "Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways". Eur. J. Biochem. 269 (2): 638–49. doi:10.1046/j.0014-2956.2001.02694.x. PMID 11856323.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Arozarena I, Matallanas D, Berciano MT, et al. (2004). "Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors" (PDF). Mol. Cell. Biol. 24 (4): 1516–30. doi:10.1128/MCB.24.4.1516-1530.2004. PMC 344182. PMID 14749369.
- Chen H, Suzuki M, Nakamura Y, et al. (2006). "Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer". Oncol. Rep. 15 (5): 1281–5. doi:10.3892/or.15.5.1281. PMID 16596198.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Ruiz S, Santos E, Bustelo XR (2007). "RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses". Mol. Cell. Biol. 27 (23): 8127–42. doi:10.1128/MCB.00912-07. PMC 2169177. PMID 17923690.
