RBM17

Protein-coding gene in the species Homo sapiens
RBM17
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2PE8, 2PEH

Identifiers
AliasesRBM17, SPF45, RNA binding motif protein 17
External IDsOMIM: 606935; MGI: 1924188; HomoloGene: 13162; GeneCards: RBM17; OMA:RBM17 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for RBM17
Genomic location for RBM17
Band10p15.1Start6,089,034 bp[1]
End6,117,457 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for RBM17
Genomic location for RBM17
Band2|2 A1Start11,590,248 bp[2]
End11,608,964 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left lobe of thyroid gland

  • body of uterus

  • body of pancreas

  • spleen

  • right uterine tube

  • right lobe of thyroid gland

  • right lung

  • upper lobe of left lung

  • appendix

  • left uterine tube
Top expressed in
  • tail of embryo

  • epiblast

  • Ileal epithelium

  • secondary oocyte

  • zygote

  • ventricular zone

  • primary oocyte

  • neural layer of retina

  • genital tubercle

  • renal corpuscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
  • nucleic acid binding
Cellular component
  • spliceosomal complex
  • nucleus
  • nucleoplasm
  • protein-containing complex
Biological process
  • mRNA processing
  • alternative mRNA splicing, via spliceosome
  • RNA splicing
  • mRNA splicing, via spliceosome
  • DNA repair
  • regulation of RNA splicing
  • regulation of alternative mRNA splicing, via spliceosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84991

76938

Ensembl

ENSG00000134453

ENSMUSG00000037197

UniProt

Q96I25

Q8JZX4

RefSeq (mRNA)

NM_032905
NM_001145547

NM_152824

RefSeq (protein)

NP_001139019
NP_116294

NP_690037

Location (UCSC)Chr 10: 6.09 – 6.12 MbChr 2: 11.59 – 11.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Splicing factor 45 is a protein that in humans is encoded by the RBM17 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134453 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037197 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Oct 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
  6. ^ "Entrez Gene: RBM17 RNA binding motif protein 17".

Further reading

  • Graveley BR (2002). "Sex, AGility, and the regulation of alternative splicing". Cell. 109 (4): 409–12. doi:10.1016/S0092-8674(02)00750-X. PMID 12086596. S2CID 15031931.
  • Lallena MJ, Chalmers KJ, Llamazares S, et al. (2002). "Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45". Cell. 109 (3): 285–96. doi:10.1016/S0092-8674(02)00730-4. PMID 12015979. S2CID 15734142.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sampath J, Long PR, Shepard RL, et al. (2003). "Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells". Am. J. Pathol. 163 (5): 1781–90. doi:10.1016/S0002-9440(10)63538-9. PMC 1892446. PMID 14578179.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Perry WL, Shepard RL, Sampath J, et al. (2005). "Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators". Cancer Res. 65 (15): 6593–600. doi:10.1158/0008-5472.CAN-03-3675. PMID 16061639.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Chaouki AS, Salz HK (2007). "Drosophila SPF45: a bifunctional protein with roles in both splicing and DNA repair". PLOS Genet. 2 (12): e178. doi:10.1371/journal.pgen.0020178. PMC 1687153. PMID 17154718.
  • Corsini L, Bonnal S, Bonna S, et al. (2007). "U2AF-homology motif interactions are required for alternative splicing regulation by SPF45". Nat. Struct. Mol. Biol. 14 (7): 620–9. doi:10.1038/nsmb1260. PMID 17589525. S2CID 22784521.


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