RBM7

Protein-coding gene in the species Homo sapiens
RBM7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2M8H, 5IQQ

Identifiers
AliasesRBM7, RNA binding motif protein 7
External IDsOMIM: 612413; MGI: 1914260; HomoloGene: 9379; GeneCards: RBM7; OMA:RBM7 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for RBM7
Genomic location for RBM7
Band11q23.2Start114,400,030 bp[1]
End114,414,203 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for RBM7
Genomic location for RBM7
Band9|9 A5.3Start48,400,001 bp[2]
End48,406,599 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cartilage tissue

  • mucosa of sigmoid colon

  • Achilles tendon

  • germinal epithelium

  • epithelium of colon

  • stromal cell of endometrium

  • tail of epididymis

  • islet of Langerhans

  • skin of hip

  • ventricular zone
Top expressed in
  • seminal vesicula

  • medial ganglionic eminence

  • mesenteric lymph nodes

  • lacrimal gland

  • left lung lobe

  • olfactory epithelium

  • conjunctival fornix

  • sciatic nerve

  • hair follicle

  • interventricular septum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleic acid binding
  • single-stranded RNA binding
  • RNA binding
  • protein binding
Cellular component
  • nucleoplasm
  • nucleolus
  • nucleus
Biological process
  • meiosis
  • regulation of alternative mRNA splicing, via spliceosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10179

67010

Ensembl

ENSG00000076053

ENSMUSG00000042396

UniProt

Q9Y580

Q9CQT2

RefSeq (mRNA)

NM_016090
NM_001286045
NM_001286046
NM_001286047
NM_001286048

NM_144948
NM_001326355
NM_001326356

RefSeq (protein)

NP_001272974
NP_001272975
NP_001272976
NP_001272977
NP_057174

NP_001313284
NP_001313285
NP_659197

Location (UCSC)Chr 11: 114.4 – 114.41 MbChr 9: 48.4 – 48.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RNA-binding motif protein 7 is a protein that in humans is encoded by the RBM7 gene.[5][6]

Interactions

RBM7 has been shown to interact with SF3B2[7] and SFRS3.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076053 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042396 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: RBM7 RNA binding motif protein 7".
  7. ^ a b Guo TB, Boros LG, Chan KC, Hikim AP, Hudson AP, Swerdloff RS, Mitchell AP, Salameh WA (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". Journal of Andrology. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Guo TB, Boros LG, Chan KC, Hikim AP, Hudson AP, Swerdloff RS, Mitchell AP, Salameh WA (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". Journal of Andrology. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Bugai A, Quaresma AJ, Friedel CC (Apr 2019). "P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress". Molecular Cell. 74 (2): 254–267.e10. doi:10.1016/j.molcel.2019.01.033. PMC 6482433. PMID 30824372.
  • Fukushima K, Satoh T, Sugihara F (Mar 2020). "Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis". Immunity. 52 (3): 542–556.e13. doi:10.1016/j.immuni.2020.02.007. PMID 32187520. Rbm7 in epithelial cells plays a critical role in the development of fibrosis by regulating ncRNA decay and thereby the production of chemokines.



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