RNF13

Protein-coding gene in the species Homo sapiens
RNF13
Identifiers
AliasesRNF13, RZF, ring finger protein 13, EIEE73, DEE73
External IDsOMIM: 609247; MGI: 1346341; HomoloGene: 13493; GeneCards: RNF13; OMA:RNF13 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for RNF13
Genomic location for RNF13
Band3q25.1Start149,812,770 bp[1]
End149,962,139 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for RNF13
Genomic location for RNF13
Band3|3 DStart57,643,483 bp[2]
End57,742,654 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • Achilles tendon

  • inferior ganglion of vagus nerve

  • C1 segment

  • subthalamic nucleus

  • parotid gland

  • optic nerve

  • retinal pigment epithelium

  • external globus pallidus

  • pars reticulata
Top expressed in
  • retinal pigment epithelium

  • deep cerebellar nuclei

  • sciatic nerve

  • globus pallidus

  • iris

  • pontine nuclei

  • lateral geniculate nucleus

  • ventral tegmental area

  • ciliary body

  • stroma of bone marrow
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • protein binding
  • ubiquitin protein ligase activity
  • ubiquitin-protein transferase activity
  • transferase activity
  • zinc ion binding
Cellular component
  • integral component of membrane
  • lysosomal membrane
  • Golgi membrane
  • nuclear inner membrane
  • endosome
  • lysosome
  • Golgi apparatus
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • late endosome membrane
  • nucleus
  • membrane
  • nucleoplasm
  • cytosol
  • intracellular membrane-bounded organelle
Biological process
  • protein ubiquitination
  • protein autoubiquitination
  • ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11342

24017

Ensembl

ENSG00000082996

ENSMUSG00000036503

UniProt

O43567

O54965

RefSeq (mRNA)
NM_007282
NM_183381
NM_183382
NM_183383
NM_183384

NM_001378285
NM_001378286
NM_001378287
NM_001378288
NM_001378289
NM_001378290
NM_001378291

NM_001113413
NM_011883
NM_001304454
NM_001304456
NM_001357080

RefSeq (protein)
NP_009213
NP_899237
NP_899239
NP_001365214
NP_001365215

NP_001365216
NP_001365217
NP_001365218
NP_001365219
NP_001365220

NP_001106884
NP_001291383
NP_001291385
NP_036013
NP_001344009

Location (UCSC)Chr 3: 149.81 – 149.96 MbChr 3: 57.64 – 57.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 13 is a protein that in humans is encoded by the RNF13 gene.[5]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000082996 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036503 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RNF13 ring finger protein 13".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Wesselkamper SC, McDowell SA, Medvedovic M, et al. (2006). "The role of metallothionein in the pathogenesis of acute lung injury". Am. J. Respir. Cell Mol. Biol. 34 (1): 73–82. doi:10.1165/rcmb.2005-0248OC. PMC 2644192. PMID 16166738.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Tranque P, Crossin KL, Cirelli C, et al. (1996). "Identification and characterization of a RING zinc finger gene (C-RZF) expressed in chicken embryo cells". Proc. Natl. Acad. Sci. U.S.A. 93 (7): 3105–9. Bibcode:1996PNAS...93.3105T. doi:10.1073/pnas.93.7.3105. PMC 39769. PMID 8610176.
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