RUFY1

Protein-coding gene in humans
RUFY1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2YQM, 2YW8

Identifiers
AliasesRUFY1, RABIP4, ZFYVE12, RUN and FYVE domain containing 1
External IDsOMIM: 610327; MGI: 2429762; HomoloGene: 23522; GeneCards: RUFY1; OMA:RUFY1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for RUFY1
Genomic location for RUFY1
Band5q35.3Start179,550,554 bp[1]
End179,610,012 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for RUFY1
Genomic location for RUFY1
Band11|11 B1.3Start50,280,113 bp[2]
End50,321,952 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • Achilles tendon

  • sural nerve

  • corpus callosum

  • ventricular zone

  • blood

  • right uterine tube

  • gastric mucosa

  • granulocyte

  • skin of leg
Top expressed in
  • primary oocyte

  • neural layer of retina

  • right kidney

  • granulocyte

  • muscle of thigh

  • zygote

  • transitional epithelium of urinary bladder

  • proximal tubule

  • retinal pigment epithelium

  • secondary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • lipid binding
  • SH3 domain binding
  • SH2 domain binding
Cellular component
  • intracellular membrane-bounded organelle
  • membrane
  • cytoplasm
  • cytosol
  • nuclear speck
  • early endosome membrane
  • endosome
  • nucleus
Biological process
  • protein transport
  • endocytosis
  • phosphatidylinositol biosynthetic process
  • regulation of endocytosis
  • small GTPase mediated signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80230

216724

Ensembl

ENSG00000284260
ENSG00000176783

ENSMUSG00000020375

UniProt

Q96T51

Q8BIJ7

RefSeq (mRNA)

NM_001040451
NM_001040452
NM_025158

NM_172557

RefSeq (protein)

NP_001035541
NP_001035542
NP_079434

NP_766145

Location (UCSC)Chr 5: 179.55 – 179.61 MbChr 11: 50.28 – 50.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene.[5][6] It is named after the RUN and FYVE domains it contains.

Interactions

RUFY1 has been shown to interact with BMX.[5]

References

  1. ^ a b c ENSG00000176783 GRCh38: Ensembl release 89: ENSG00000284260, ENSG00000176783 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020375 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Yang J, Kim O, Wu J, Qiu Y (Aug 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.
  6. ^ "Entrez Gene: RUFY1 RUN and FYVE domain containing 1".

Further reading

  • Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1637–42. doi:10.1073/pnas.031586998. PMC 29309. PMID 11172003.
  • Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJ (2004). "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes". Mol. Biol. Cell. 15 (2): 611–24. doi:10.1091/mbc.E03-05-0343. PMC 329268. PMID 14617813.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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