SASH1

Protein-coding gene in the species Homo sapiens

SASH1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2EBP

Identifiers
AliasesSASH1, SH3D6A, dJ323M4, dJ323M4.1, SAM and SH3 domain containing 1, DUH1, CAPOK
External IDsOMIM: 607955; MGI: 1917347; HomoloGene: 69182; GeneCards: SASH1; OMA:SASH1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SASH1
Genomic location for SASH1
Band6q24.3-q25.1Start148,272,304 bp[1]
End148,552,044 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SASH1
Genomic location for SASH1
Band10|10 A1Start8,597,983 bp[2]
End8,761,814 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • synovial joint

  • external globus pallidus

  • skin of hip

  • subthalamic nucleus

  • skin of thigh

  • inferior ganglion of vagus nerve

  • oral cavity

  • pars reticulata

  • Achilles tendon

  • lateral nuclear group of thalamus
Top expressed in
  • stroma of bone marrow

  • transitional epithelium of urinary bladder

  • medial geniculate nucleus

  • lateral geniculate nucleus

  • substantia nigra

  • suprachiasmatic nucleus

  • ventral tegmental area

  • medial dorsal nucleus

  • lateral hypothalamus

  • deep cerebellar nuclei
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • mitogen-activated protein kinase kinase kinase binding
  • molecular adaptor activity
  • protein C-terminus binding
  • protein kinase binding
Cellular component
  • protein-containing complex
Biological process
  • positive regulation of endothelial cell migration
  • positive regulation of lipopolysaccharide-mediated signaling pathway
  • positive regulation of JUN kinase activity
  • regulation of protein K63-linked ubiquitination
  • positive regulation of p38MAPK cascade
  • regulation of protein autoubiquitination
  • protein polyubiquitination
  • positive regulation of NIK/NF-kappaB signaling
  • positive regulation of angiogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23328

70097

Ensembl

ENSG00000111961

ENSMUSG00000015305

UniProt

O94885

P59808

RefSeq (mRNA)
NM_015278
NM_001346505
NM_001346506
NM_001346507
NM_001346508

NM_001346509

NM_175155

RefSeq (protein)
NP_001333434
NP_001333435
NP_001333436
NP_001333437
NP_001333438

NP_056093

NP_780364

Location (UCSC)Chr 6: 148.27 – 148.55 MbChr 10: 8.6 – 8.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SAM and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SASH1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111961 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015305 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S (May 2003). "SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer". Oncogene. 22 (19): 2972–83. doi:10.1038/sj.onc.1206474. PMID 12771949. S2CID 7267561.
  7. ^ "Entrez Gene: SASH1 SAM and SH3 domain containing 1".

Further reading

  • Rimkus C, Martini M, Friederichs J, et al. (2007). "Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer". Br. J. Cancer. 95 (10): 1419–23. doi:10.1038/sj.bjc.6603452. PMC 2360597. PMID 17088907.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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  • 2dl0: Solution structure of the SAM-domain of the SAM and SH3 domain containing protein 1
    2dl0: Solution structure of the SAM-domain of the SAM and SH3 domain containing protein 1


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