SCFD1

Protein-coding gene in the species Homo sapiens

SCFD1

Identifiers

Aliases

SCFD1, C14orf163, RA410, SLY1, SLY1P, STXBP1L2, sec1 family domain containing 1

External IDs

OMIM: 618207; MGI: 1924233; HomoloGene: 5650; GeneCards: SCFD1; OMA:SCFD1 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q12	Start	30,622,291 bp^[1]
Band	14q12	End	30,737,694 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 B3	Start	51,424,293 bp^[2]
Band	12\|12 B3	End	51,496,884 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

body of pancreas

anterior pituitary

parotid gland

corpus epididymis

oral cavity

mucosa of paranasal sinus

islet of Langerhans

biceps brachii

bone marrow cells

Top expressed in

seminal vesicula

parotid gland

islet of Langerhans

calvaria

dermis

lobe of prostate

efferent ductule

olfactory epithelium

pituitary gland

Gonadal ridge

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein N-terminus binding protein binding syntaxin binding protein-containing complex binding
Cellular component	cytoplasm cytosol Golgi apparatus endoplasmic reticulum membrane membrane cis-Golgi network plasma membrane Golgi transport complex Golgi-associated vesicle Golgi cisterna membrane endoplasmic reticulum
Biological process	negative regulation of autophagosome assembly regulation of ER to Golgi vesicle-mediated transport response to hypoxia regulation of protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum toxin transport post-Golgi vesicle-mediated transport vesicle docking involved in exocytosis COPII vesicle coating cell morphogenesis protein transport response to toxic substance vesicle-mediated transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23256


76983

Ensembl


ENSG00000092108


ENSMUSG00000020952

UniProt


Q8WVM8


Q8BRF7

RefSeq (mRNA)

NM_001257376 NM_001283031 NM_001283032 NM_001283033 NM_016106
NM_182835


NM_029825 NM_001306178

RefSeq (protein)

NP_001244305 NP_001269960 NP_001269961 NP_001269962 NP_057190
NP_878255


NP_001293107 NP_084101

Location (UCSC)

Chr 14: 30.62 – 30.74 Mb

Chr 12: 51.42 – 51.5 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sec1 family domain-containing protein 1 is a protein that in humans is encoded by the SCFD1 gene.^[5]

Interactions

SCFD1 has been shown to interact with USO1.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092108 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020952 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SCFD1 sec1 family domain containing 1".
^ Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
^ Allan BB, Moyer BD, Balch WE (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. Bibcode:2000Sci...289..444A. doi:10.1126/science.289.5478.444. PMID 10903204.

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Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
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