SCGB3A1

Protein-coding gene in the species Homo sapiens

SCGB3A1

Identifiers

Aliases

SCGB3A1, HIN-1, HIN1, LU105, PnSP-2, UGRP2, secretoglobin family 3A member 1

External IDs

OMIM: 606500; MGI: 1915912; HomoloGene: 14160; GeneCards: SCGB3A1; OMA:SCGB3A1 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q35.3	Start	180,590,105 bp^[1]
Band	5q35.3	End	180,591,499 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 B1.2\|11 29.75 cM	Start	49,554,437 bp^[2]
Band	11 B1.2\|11 29.75 cM	End	49,555,945 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

trachea

bronchial epithelial cell

parotid gland

olfactory zone of nasal mucosa

pancreatic ductal cell

right lung

urethra

palpebral conjunctiva

lower lobe of lung

upper lobe of lung

Top expressed in

trachea

right lung

right lung lobe

epithelium of trachea

embryo

left lung

main bronchus

embryo

Epithelium of main bronchus

submucosa of trachea

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	cytokine activity
Cellular component	extracellular region extracellular exosome extracellular space
Biological process	negative regulation of cell growth regulation of cell population proliferation positive regulation of myoblast fusion regulation of signaling receptor activity signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


92304


68662

Ensembl


ENSG00000161055


ENSMUSG00000064057

UniProt


Q96QR1


Q920D7

RefSeq (mRNA)


NM_052863


NM_054037 NM_170727

RefSeq (protein)


NP_443095


NP_473378 NP_733923

Location (UCSC)

Chr 5: 180.59 – 180.59 Mb

Chr 11: 49.55 – 49.56 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Secretoglobin family 3A member 1 is a protein that in humans is encoded by the SCGB3A1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161055 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000064057 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovic J, Polyak K (August 2001). "HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 98 (17): 9796–801. Bibcode:2001PNAS...98.9796K. doi:10.1073/pnas.171138398. PMC 55532. PMID 11481438.
^ "Entrez Gene: SCGB3A1 secretoglobin, family 3A, member 1".

Porter D, Lahti-Domenici J, Torres-Arzayus M, Chin L, Polyak K (June 2002). "Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues". Mechanisms of Development. 114 (1–2): 201–4. doi:10.1016/S0925-4773(02)00056-4. PMID 12175512. S2CID 1770009.
Reynolds SD, Reynolds PR, Pryhuber GS, Finder JD, Stripp BR (December 2002). "Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways". American Journal of Respiratory and Critical Care Medicine. 166 (11): 1498–509. doi:10.1164/rccm.200204-285OC. PMID 12406855.
Niimi T, Copeland NG, Gilbert DJ, Jenkins NA, Srisodsai A, Zimonjic DB, Keck-Waggoner CL, Popescu NC, Kimura S (2003). "Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family". Cytogenetic and Genome Research. 97 (1–2): 120–7. doi:10.1159/000064067. PMID 12438750. S2CID 37313915.
Krop I, Maguire P, Lahti-Domenici J, Lodeiro G, Richardson A, Johannsdottir HK, Nevanlinna H, Borg A, Gelman R, Barkardottir RB, Lindblom A, Polyak K (May 2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors". Cancer Research. 63 (9): 2024–7. PMID 12727813.
Bin LH, Nielson LD, Liu X, Mason RJ, Shu HB (July 2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair". Journal of Immunology. 171 (2): 924–30. doi:10.4049/jimmunol.171.2.924. PMID 12847263.
Fackler MJ, McVeigh M, Evron E, Garrett E, Mehrotra J, Polyak K, Sukumar S, Argani P (December 2003). "DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma". International Journal of Cancer. 107 (6): 970–5. doi:10.1002/ijc.11508. PMID 14601057. S2CID 43639879.
Tisserand P, Fouquet C, Barrois M, Gallou C, Dendale R, Stoppa-Lyonnet D, Sastre-Garau X, Fourquet A, Soussi T (2004). "Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors". Cancer Biology & Therapy. 2 (5): 559–63. doi:10.4161/cbt.2.5.511. PMID 14614327. S2CID 25141850.
Marchetti A, Barassi F, Martella C, Chella A, Salvatore S, Castrataro A, Mucilli F, Sacco R, Buttitta F (February 2004). "Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome". Clinical Cancer Research. 10 (4): 1338–43. doi:10.1158/1078-0432.CCR-1174-03. PMID 14977834.
Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Krop I, Player A, Tablante A, Taylor-Parker M, Lahti-Domenici J, Fukuoka J, Batra SK, Papadopoulos N, Richards WG, Sugarbaker DJ, Wright RL, Shim J, Stamey TA, Sellers WR, Loda M, Meyerson M, Hruban R, Jen J, Polyak K (September 2004). "Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types". Molecular Cancer Research. 2 (9): 489–94. doi:10.1158/1541-7786.489.2.9. PMID 15383627. S2CID 25730252.
Shigematsu H, Suzuki M, Takahashi T, Miyajima K, Toyooka S, Shivapurkar N, Tomlinson GE, Mastrangelo D, Pass HI, Brambilla E, Sathyanarayana UG, Czerniak B, Fujisawa T, Shimizu N, Gazdar AF (February 2005). "Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies". International Journal of Cancer. 113 (4): 600–4. doi:10.1002/ijc.20622. PMID 15472908. S2CID 1168580.
Krop I, Parker MT, Bloushtain-Qimron N, Porter D, Gelman R, Sasaki H, Maurer M, Terry MB, Parsons R, Polyak K (November 2005). "HIN-1, an inhibitor of cell growth, invasion, and AKT activation". Cancer Research. 65 (21): 9659–69. doi:10.1158/0008-5472.CAN-05-1663. PMID 16266985.
Yang Q, Kiernan CM, Tian Y, Salwen HR, Chlenski A, Brumback BA, London WB, Cohn SL (June 2007). "Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome". Clinical Cancer Research. 13 (11): 3191–7. doi:10.1158/1078-0432.CCR-06-2846. PMID 17545522. S2CID 13614534.
Wu Q, Lothe RA, Ahlquist T, Silins I, Tropé CG, Micci F, Nesland JM, Suo Z, Lind GE (July 2007). "DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets". Molecular Cancer. 6: 45. doi:10.1186/1476-4598-6-45. PMC 1964763. PMID 17623056.