SCMH1

Protein-coding gene in the species Homo sapiens

SCMH1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2P0K

Identifiers

Aliases

SCMH1, Scml3, sex comb on midleg homolog 1 (Drosophila), Scm polycomb group protein homolog 1

External IDs

OMIM: 616396; MGI: 1352762; HomoloGene: 32146; GeneCards: SCMH1; OMA:SCMH1 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p34.2	Start	41,027,200 bp^[1]
Band	1p34.2	End	41,242,154 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 D2.1\|4 56.52 cM	Start	120,262,478 bp^[2]
Band	4 D2.1\|4 56.52 cM	End	120,387,383 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

muscle layer of sigmoid colon

popliteal artery

tibial arteries

body of uterus

gastric mucosa

thoracic aorta

ascending aorta

Descending thoracic aorta

right coronary artery

left uterine tube

Top expressed in

saccule

Rostral migratory stream

tail of embryo

ectoderm

otic vesicle

neural layer of retina

zygote

otic placode

genital tubercle

secondary oocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	chromocenter nucleoplasm nucleus
Biological process	multicellular organism development chromatin remodeling regulation of transcription, DNA-templated transcription, DNA-templated spermatogenesis anterior/posterior pattern specification negative regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


22955


29871

Ensembl


ENSG00000010803


ENSMUSG00000000085

UniProt


Q96GD3


Q8K214

RefSeq (mRNA)

NM_001031694 NM_001172218 NM_001172219 NM_001172220 NM_001172221
NM_001172222 NM_012236 NM_001350667 NM_001350668 NM_001394299 NM_001394300 NM_001394301 NM_001394302 NM_001394303 NM_001394304 NM_001394305 NM_001394306 NM_001394307 NM_001394308 NM_001394309 NM_001394311

NM_001159630 NM_013883 NM_001355423 NM_001355424 NM_001379184
NM_001379185 NM_001379186

RefSeq (protein)

NP_001026864 NP_001165689 NP_001165690 NP_001165691 NP_001165692
NP_001165693 NP_036368 NP_001337596 NP_001337597

NP_001153102 NP_038911 NP_001342352 NP_001342353 NP_001366113
NP_001366114 NP_001366115 NP_001391019 NP_001391031 NP_001391032

Location (UCSC)

Chr 1: 41.03 – 41.24 Mb

Chr 4: 120.26 – 120.39 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Polycomb protein SCMH1 is a protein that in humans is encoded by the SCMH1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000010803 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000085 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Berger J, Kurahashi H, Takihara Y, Shimada K, Brock HW, Randazzo F (September 1999). "The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34". Gene. 237 (1): 185–91. doi:10.1016/S0378-1119(99)00285-1. PMID 10524249.
^ "Entrez Gene: SCMH1 sex comb on midleg homolog 1 (Drosophila)".

Tomotsune D, Takihara Y, Berger J, Duhl D, Joo S, Kyba M, Shirai M, Ohta H, Matsuda Y, Honda BM, Simon J, Shimada K, Brock HW, Randazzo F (December 1999). "A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro". Differentiation; Research in Biological Diversity. 65 (4): 229–39. doi:10.1046/j.1432-0436.1999.6540229.x. PMID 10653359.
Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (September 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M (February 2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions". Nature. 427 (6976): 749–53. Bibcode:2004Natur.427..749L. doi:10.1038/nature02305. hdl:11858/00-001M-0000-0012-EE32-1. PMID 14973489. S2CID 8020382.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.