SCYL3

Protein-coding gene in humans
SCYL3
Identifiers
AliasesSCYL3, PACE-1, PACE1, SCY1 like pseudokinase 3
External IDsOMIM: 608192; MGI: 1921385; HomoloGene: 10706; GeneCards: SCYL3; OMA:SCYL3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SCYL3
Genomic location for SCYL3
Band1q24.2Start169,849,631 bp[1]
End169,894,267 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for SCYL3
Genomic location for SCYL3
Band1|1 H2.1- H2.2Start163,756,669 bp[2]
End163,782,695 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • secondary oocyte

  • amniotic fluid

  • pancreatic ductal cell

  • epithelium of nasopharynx

  • palpebral conjunctiva

  • Epithelium of choroid plexus

  • Achilles tendon

  • endothelial cell

  • testicle
Top expressed in
  • superior cervical ganglion

  • spermatocyte

  • Paneth cell

  • granulocyte

  • otolith organ

  • facial motor nucleus

  • utricle

  • dorsal striatum

  • substantia nigra

  • mesenteric lymph nodes
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ATP binding
  • kinase activity
Cellular component
  • cytoplasm
  • Golgi apparatus
  • cell projection
  • lamellipodium
Biological process
  • protein phosphorylation
  • cell migration
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57147

240880

Ensembl

ENSG00000000457

ENSMUSG00000026584

UniProt

Q8IZE3

Q9DBQ7

RefSeq (mRNA)

NM_020423
NM_181093

NM_001286002
NM_001286003
NM_028776
NM_001357426

RefSeq (protein)

NP_065156
NP_851607

NP_001272931
NP_001272932
NP_083052
NP_001344355

Location (UCSC)Chr 1: 169.85 – 169.89 MbChr 1: 163.76 – 163.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein-associating with the carboxyl-terminal domain of ezrin is a protein that in humans is encoded by the SCYL3 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000000457 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026584 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sullivan A, Uff CR, Isacke CM, Thorne RF (Mar 2003). "PACE-1, a novel protein that interacts with the C-terminal domain of ezrin". Exp Cell Res. 284 (2): 224–38. doi:10.1016/S0014-4827(02)00054-X. PMID 12651155.
  6. ^ "Entrez Gene: SCYL3 SCY1-like 3 (S. cerevisiae)".

Further reading

  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Maurer-Stroh S, Gouda M, Novatchkova M, et al. (2004). "MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins". Genome Biol. 5 (3): R21. doi:10.1186/gb-2004-5-3-r21. PMC 395771. PMID 15003124.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.


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