SEC22A

Protein-coding gene in the species Homo sapiens
SEC22A
Identifiers
AliasesSEC22A, SEC22L2, SEC22 homolog A, vesicle trafficking protein
External IDsOMIM: 612442; MGI: 2447876; HomoloGene: 8246; GeneCards: SEC22A; OMA:SEC22A - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SEC22A
Genomic location for SEC22A
Band3q21.1Start123,201,927 bp[1]
End123,274,136 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for SEC22A
Genomic location for SEC22A
Band16|16 B3Start35,131,501 bp[2]
End35,184,288 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • Achilles tendon

  • islet of Langerhans

  • gonad

  • left testis

  • testicle

  • right testis

  • ventricular zone

  • ganglionic eminence

  • stromal cell of endometrium
Top expressed in
  • spermatocyte

  • medullary collecting duct

  • primary oocyte

  • spermatid

  • secondary oocyte

  • renal corpuscle

  • right kidney

  • epithelium of lens

  • zygote

  • interventricular septum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • SNAP receptor activity
  • protein binding
  • SNARE binding
  • transporter activity
Cellular component
  • integral component of membrane
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • membrane
  • SNARE complex
Biological process
  • protein transport
  • vesicle-mediated transport
  • vesicle fusion with Golgi apparatus
  • exocytosis
  • endoplasmic reticulum to Golgi vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26984

317717

Ensembl

ENSG00000121542

ENSMUSG00000034473

UniProt

Q96IW7

Q8BH47

RefSeq (mRNA)

NM_012430

NM_133704

RefSeq (protein)

NP_036562

NP_598465

Location (UCSC)Chr 3: 123.2 – 123.27 MbChr 16: 35.13 – 35.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vesicle-trafficking protein SEC22a is a protein that in humans is encoded by the SEC22A gene.[5][6][7]

The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. There is evidence for the use of multiple poly A sites in this gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121542 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034473 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
  6. ^ Tang BL, Low DY, Hong W (Mar 1998). "Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24". Biochem Biophys Res Commun. 243 (3): 885–91. doi:10.1006/bbrc.1998.8194. PMID 9501016.
  7. ^ a b "Entrez Gene: SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)".

Further reading

  • Hay JC, Hirling H, Scheller RH (1996). "Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus". J. Biol. Chem. 271 (10): 5671–9. doi:10.1074/jbc.271.10.5671. PMID 8621431.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mancias JD, Goldberg J (2007). "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope". Mol. Cell. 26 (3): 403–14. doi:10.1016/j.molcel.2007.03.017. PMID 17499046.


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