SEC23IP

Protein-coding gene in the species Homo sapiens
SEC23IP
Identifiers
AliasesSEC23IP, P125, P125A, MSTP053, SEC23 interacting protein, iPLA1beta
External IDsOMIM: 617852; MGI: 2450915; HomoloGene: 38288; GeneCards: SEC23IP; OMA:SEC23IP - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for SEC23IP
Genomic location for SEC23IP
Band10q26.11-q26.12Start119,892,730 bp[1]
End119,944,657 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SEC23IP
Genomic location for SEC23IP
Band7 F3|7 70.51 cMStart128,346,667 bp[2]
End128,386,560 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of colon

  • stromal cell of endometrium

  • secondary oocyte

  • Achilles tendon

  • islet of Langerhans

  • monocyte

  • smooth muscle tissue

  • mucosa of sigmoid colon

  • ventricular zone

  • cartilage tissue
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • primary oocyte

  • calvaria

  • vestibular membrane of cochlear duct

  • cumulus cell

  • yolk sac

  • endothelial cell of lymphatic vessel

  • gastrula
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • phospholipase activity
  • RNA binding
Cellular component
  • cytoplasm
  • ER to Golgi transport vesicle membrane
  • cytosol
  • endoplasmic reticulum
  • membrane
  • cytoplasmic vesicle
  • endoplasmic reticulum-Golgi intermediate compartment
  • Golgi membrane
  • COPII-coated ER to Golgi transport vesicle
  • Golgi apparatus
  • intracellular membrane-bounded organelle
Biological process
  • COPII vesicle coating
  • intracellular protein transport
  • Golgi organization
  • endoplasmic reticulum to Golgi vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11196

207352

Ensembl

ENSG00000107651

ENSMUSG00000055319

UniProt

Q9Y6Y8

Q6NZC7

RefSeq (mRNA)

NM_007190

NM_001029982

RefSeq (protein)

NP_009121

n/a

Location (UCSC)Chr 10: 119.89 – 119.94 MbChr 7: 128.35 – 128.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.[5][6]

COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107651 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055319 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M (Aug 1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins". J Biol Chem. 274 (29): 20505–12. doi:10.1074/jbc.274.29.20505. PMID 10400679.
  6. ^ a b "Entrez Gene: SEC23IP SEC23 interacting protein".

Further reading

  • Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID 16510448.
  • Shimoi W, Ezawa I, Nakamoto K, et al. (2005). "p125 is localized in endoplasmic reticulum exit sites and involved in their organization". J. Biol. Chem. 280 (11): 10141–8. doi:10.1074/jbc.M409673200. PMID 15623529.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mizoguchi T, Nakajima K, Hatsuzawa K, et al. (2001). "Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein". Biochem. Biophys. Res. Commun. 279 (1): 144–9. doi:10.1006/bbrc.2000.3846. PMID 11112430.


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