SEC24C

Protein-coding gene in the species Homo sapiens
SEC24C
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

3EH2

Identifiers
AliasesSEC24C, SEC24 homolog C, COPII coat complex component
External IDsOMIM: 607185; MGI: 1919746; HomoloGene: 3615; GeneCards: SEC24C; OMA:SEC24C - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for SEC24C
Genomic location for SEC24C
Band10q22.2Start73,744,372 bp[1]
End73,772,161 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for SEC24C
Genomic location for SEC24C
Band14|14 A3Start20,724,376 bp[2]
End20,744,920 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of pharynx

  • islet of Langerhans

  • granulocyte

  • stromal cell of endometrium

  • anterior pituitary

  • right adrenal gland

  • left adrenal gland

  • right adrenal cortex

  • left adrenal cortex

  • smooth muscle tissue
Top expressed in
  • tail of embryo

  • genital tubercle

  • neural layer of retina

  • spermatocyte

  • yolk sac

  • esophagus

  • muscle of thigh

  • ventricular zone

  • granulocyte

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • SNARE binding
  • zinc ion binding
  • metal ion binding
Cellular component
  • cytoplasm
  • endoplasmic reticulum membrane
  • membrane
  • Golgi membrane
  • endoplasmic reticulum
  • COPII vesicle coat
  • cytosol
  • ER to Golgi transport vesicle membrane
  • cytoplasmic vesicle
Biological process
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • antigen processing and presentation of peptide antigen via MHC class I
  • COPII vesicle coating
  • protein transport
  • intracellular protein transport
  • vesicle-mediated transport
  • in utero embryonic development
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • COPII-coated vesicle cargo loading
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9632

218811

Ensembl

ENSG00000176986

ENSMUSG00000039367

UniProt

P53992

n/a

RefSeq (mRNA)

NM_004922
NM_198597

NM_001168273
NM_172596

RefSeq (protein)

NP_004913
NP_940999

n/a

Location (UCSC)Chr 10: 73.74 – 73.77 MbChr 14: 20.72 – 20.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein transport protein Sec24C is a protein that in humans is encoded by the SEC24C gene.[5][6][7]

Function

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified.[7]

Interactions

SEC24C has been shown to interact with SEC23A.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176986 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039367 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tani K, Oyama Y, Hatsuzawa K, Tagaya M (May 1999). "Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p". FEBS Lett. 447 (2–3): 247–50. doi:10.1016/S0014-5793(99)00303-8. PMID 10214955. S2CID 41796761.
  6. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  7. ^ a b "Entrez Gene: SEC24C SEC24 related gene family, member C (S. cerevisiae)".
  8. ^ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Mar 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.

Further reading

  • Tang BL, Kausalya J, Low DY, Lock ML, Hong W (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
  • Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP (2004). "Regulation of a COPII component by cytosolic O-glycosylation during mitosis". FEBS Lett. 561 (1–3): 44–50. doi:10.1016/S0014-5793(04)00109-7. PMID 15013749. S2CID 24041746.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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