SEMA6C

Protein-coding gene in the species Homo sapiens
SEMA6C
Identifiers
AliasesSEMA6C, SEMAY, m-SemaY, m-SemaY2, semaphorin 6C, Sema-Y
External IDsOMIM: 609294; MGI: 1338032; HomoloGene: 7931; GeneCards: SEMA6C; OMA:SEMA6C - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SEMA6C
Genomic location for SEMA6C
Band1q21.3Start151,131,685 bp[1]
End151,146,631 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SEMA6C
Genomic location for SEMA6C
Band3|3 F2.1Start95,160,457 bp[2]
End95,174,024 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • apex of heart

  • gastrocnemius muscle

  • right hemisphere of cerebellum

  • right testis

  • ganglionic eminence

  • left testis

  • Skeletal muscle tissue of rectus abdominis

  • triceps brachii muscle

  • left ventricle
Top expressed in
  • muscle of thigh

  • triceps brachii muscle

  • temporal muscle

  • sternocleidomastoid muscle

  • spermatocyte

  • vastus lateralis muscle

  • intercostal muscle

  • pyloric antrum

  • tibialis anterior muscle

  • ankle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • semaphorin receptor binding
  • chemorepellent activity
  • neuropilin binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
  • cytoplasm
  • cell surface
  • extracellular space
Biological process
  • multicellular organism development
  • cell differentiation
  • nervous system development
  • axon guidance
  • negative regulation of axon extension
  • neural crest cell migration
  • positive regulation of cell migration
  • negative regulation of axon extension involved in axon guidance
  • negative chemotaxis
  • semaphorin-plexin signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10500

20360

Ensembl

ENSG00000143434

ENSMUSG00000038777

UniProt

Q9H3T2

Q9WTM3

RefSeq (mRNA)

NM_001178061
NM_001178062
NM_030913

NM_001272024
NM_011351

RefSeq (protein)

NP_001171532
NP_001171533
NP_112175

NP_001258953
NP_035481

Location (UCSC)Chr 1: 151.13 – 151.15 MbChr 3: 95.16 – 95.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Semaphorin-6C is a protein that in humans is encoded by the SEMA6C gene.[5][6]

This gene product is a member of the semaphoring family of proteins. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143434 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038777 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Qu X, Wei H, Zhai Y, Que H, Chen Q, Tang F, Wu Y, Xing G, Zhu Y, Liu S, Fan M, He F (Sep 2002). "Identification, characterization, and functional study of the two novel human members of the semaphorin gene family". J Biol Chem. 277 (38): 35574–85. doi:10.1074/jbc.M206451200. PMID 12110693.
  6. ^ a b "Entrez Gene: SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C".

Further reading

  • Pasterkamp RJ, Verhaagen J (2001). "Emerging roles for semaphorins in neural regeneration". Brain Res. Brain Res. Rev. 35 (1): 36–54. doi:10.1016/S0165-0173(00)00050-3. PMID 11245885. S2CID 20402160.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


  • v
  • t
  • e