SEPT14

Protein-coding gene in the species Homo sapiens
SEPTIN14
Identifiers
AliasesSEPTIN14, septin 14, SEPT14
External IDsOMIM: 612140; MGI: 1921472; HomoloGene: 87501; GeneCards: SEPTIN14; OMA:SEPTIN14 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for SEPTIN14
Genomic location for SEPTIN14
Band7p11.2Start55,793,540 bp[1]
End55,862,755 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SEPTIN14
Genomic location for SEPTIN14
Band5|5 G1.3Start129,760,455 bp[2]
End129,785,576 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • gonad

  • testicle

  • blood

  • monocyte

  • endometrium

  • anterior pituitary

  • right lobe of liver

  • spleen
Top expressed in
  • zygote

  • spermatocyte

  • secondary oocyte

  • spermatid

  • primary oocyte

  • testicle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • protein binding
  • GTPase activity
  • molecular adaptor activity
Cellular component
  • cytoplasm
  • cytoskeleton
  • septin ring
  • microtubule cytoskeleton
  • septin complex
  • septin filament array
Biological process
  • cell cycle
  • cell division
  • mitotic cytokinesis
  • septin ring assembly
  • cilium assembly
  • cytoskeleton-dependent cytokinesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

346288

74222

Ensembl

ENSG00000154997

ENSMUSG00000034219

UniProt

Q6ZU15

Q9DA97

RefSeq (mRNA)

NM_207366

NM_028826

RefSeq (protein)

NP_997249

NP_083102

Location (UCSC)Chr 7: 55.79 – 55.86 MbChr 5: 129.76 – 129.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin 14 is a protein that in humans is encoded by the SEPT14 gene.[5]

Function

SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154997 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034219 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Septin 14".

Further reading

  • Peterson EA, Kalikin LM, Steels JD, Estey MP, Trimble WS, Petty EM (November 2007). "Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin". Mammalian Genome. 18 (11): 796–807. doi:10.1007/s00335-007-9065-x. PMID 17922164. S2CID 9906543.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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