SERINC1

Protein-coding gene in the species Homo sapiens
SERINC1
Identifiers
AliasesSERINC1, TDE1L, TDE2, TMS-2, TMS2, serine incorporator 1
External IDsOMIM: 614548; MGI: 1926228; HomoloGene: 41334; GeneCards: SERINC1; OMA:SERINC1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SERINC1
Genomic location for SERINC1
Band6q22.31Start122,443,351 bp[1]
End122,471,807 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SERINC1
Genomic location for SERINC1
Band10|10 B4Start57,391,870 bp[2]
End57,408,626 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pons

  • lateral nuclear group of thalamus

  • orbitofrontal cortex

  • postcentral gyrus

  • Pars compacta

  • subthalamic nucleus

  • pars reticulata

  • superior vestibular nucleus

  • external globus pallidus

  • C1 segment
Top expressed in
  • lobe of cerebellum

  • cerebellar vermis

  • ventral tegmental area

  • medial dorsal nucleus

  • dorsomedial hypothalamic nucleus

  • dorsal tegmental nucleus

  • medial geniculate nucleus

  • subiculum

  • paraventricular nucleus of hypothalamus

  • mammillary body
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • enzyme binding
  • protein-macromolecule adaptor activity
  • L-serine transmembrane transporter activity
Cellular component
  • plasma membrane
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • membrane
  • integral component of membrane
Biological process
  • phosphatidylserine metabolic process
  • positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
  • positive regulation of serine C-palmitoyltransferase activity
  • sphingolipid metabolic process
  • phospholipid biosynthetic process
  • lipid metabolism
  • L-serine transport
  • membrane biogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57515

56442

Ensembl

ENSG00000111897

ENSMUSG00000019877

UniProt

Q9NRX5

Q9QZI8

RefSeq (mRNA)

NM_020755

NM_019760

RefSeq (protein)

NP_065806

NP_062734

Location (UCSC)Chr 6: 122.44 – 122.47 MbChr 10: 57.39 – 57.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine incorporator 1 is a protein that in humans is encoded by the SERINC1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111897 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019877 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Grossman TR, Luque JM, Nelson N (Apr 2000). "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain". J Exp Biol. 203 (Pt 3): 447–57. doi:10.1242/jeb.203.3.447. hdl:10261/308420. PMID 10637174.
  6. ^ "Entrez Gene: SERINC1 serine incorporator 1".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.


  • v
  • t
  • e