SESN1 |
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Identifiers |
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Aliases | SESN1, PA26, SEST1, sestrin 1 |
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External IDs | OMIM: 606103; MGI: 2155278; HomoloGene: 8697; GeneCards: SESN1; OMA:SESN1 - orthologs |
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Gene location (Human) |
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![Chromosome 6 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/300px-Ideogram_human_chromosome_6.svg.png) | Chr. | Chromosome 6 (human)[1] |
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| Band | 6q21 | Start | 108,984,309 bp[1] |
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End | 109,094,846 bp[1] |
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Gene location (Mouse) |
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![Chromosome 10 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/260px-Ideogram_house_mouse_chromosome_10.svg.png) | Chr. | Chromosome 10 (mouse)[2] |
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| Band | 10 B2|10 22.77 cM | Start | 41,685,931 bp[2] |
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End | 41,784,420 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Skeletal muscle tissue of rectus abdominis
- muscle of thigh
- thoracic diaphragm
- glutes
- gastrocnemius muscle
- muscle of arm
- biceps brachii
- Skeletal muscle tissue of biceps brachii
- triceps brachii muscle
- right ovary
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| Top expressed in | - myocardium of ventricle
- intercostal muscle
- conjunctival fornix
- ciliary body
- cerebellar vermis
- interventricular septum
- iris
- lobe of cerebellum
- retinal pigment epithelium
- vestibular membrane of cochlear duct
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - oxidoreductase activity
- peroxiredoxin activity
- protein binding
- leucine binding
- oxidoreductase activity, acting on peroxide as acceptor
| Cellular component | - cytosol
- cytoplasm
- GATOR2 complex
- nucleus
- fibrillar center
- TORC2 complex
| Biological process | - regulation of response to reactive oxygen species
- reactive oxygen species metabolic process
- cellular oxidant detoxification
- negative regulation of TORC1 signaling
- cellular response to amino acid starvation
- cellular response to glucose starvation
- positive regulation of macroautophagy
- cellular response to amino acid stimulus
- cellular response to leucine
- cellular response to leucine starvation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_014454 NM_001199933 NM_001199934 |
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RefSeq (protein) | |
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NP_001186862 NP_001186863 NP_055269 |
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Location (UCSC) | Chr 6: 108.98 – 109.09 Mb | Chr 10: 41.69 – 41.78 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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