SESN1

Protein-coding gene in the species Homo sapiens

SESN1

Identifiers

Aliases

SESN1, PA26, SEST1, sestrin 1

External IDs

OMIM: 606103; MGI: 2155278; HomoloGene: 8697; GeneCards: SESN1; OMA:SESN1 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q21	Start	108,984,309 bp^[1]
Band	6q21	End	109,094,846 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 B2\|10 22.77 cM	Start	41,685,931 bp^[2]
Band	10 B2\|10 22.77 cM	End	41,784,420 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Skeletal muscle tissue of rectus abdominis

muscle of thigh

thoracic diaphragm

glutes

gastrocnemius muscle

muscle of arm

biceps brachii

Skeletal muscle tissue of biceps brachii

triceps brachii muscle

right ovary

Top expressed in

myocardium of ventricle

intercostal muscle

conjunctival fornix

ciliary body

cerebellar vermis

interventricular septum

iris

lobe of cerebellum

retinal pigment epithelium

vestibular membrane of cochlear duct

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	oxidoreductase activity peroxiredoxin activity protein binding leucine binding oxidoreductase activity, acting on peroxide as acceptor
Cellular component	cytosol cytoplasm GATOR2 complex nucleus fibrillar center TORC2 complex
Biological process	regulation of response to reactive oxygen species reactive oxygen species metabolic process cellular oxidant detoxification negative regulation of TORC1 signaling cellular response to amino acid starvation cellular response to glucose starvation positive regulation of macroautophagy cellular response to amino acid stimulus cellular response to leucine cellular response to leucine starvation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


27244


140742

Ensembl


ENSG00000080546


ENSMUSG00000038332

UniProt


Q9Y6P5


P58006

RefSeq (mRNA)


NM_014454 NM_001199933 NM_001199934


NM_001013370 NM_001162908

RefSeq (protein)


NP_001186862 NP_001186863 NP_055269


NP_001013388 NP_001156380

Location (UCSC)

Chr 6: 108.98 – 109.09 Mb

Chr 10: 41.69 – 41.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080546 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038332 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: sestrin 1".
^ Buckbinder L, Talbott R, Seizinger BR, Kley N (October 1994). "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (22): 10640–4. Bibcode:1994PNAS...9110640B. doi:10.1073/pnas.91.22.10640. PMC 45077. PMID 7938006.
^ Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene. 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID 9926927.