SFRS11

Protein-coding gene in the species Homo sapiens
SRSF11
Identifiers
AliasesSRSF11, NET2, SFRS11, dJ677H15.2, p54, serine/arginine-rich splicing factor 11, serine and arginine rich splicing factor 11
External IDsOMIM: 602010; MGI: 1916457; HomoloGene: 36164; GeneCards: SRSF11; OMA:SRSF11 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SRSF11
Genomic location for SRSF11
Band1p31.1Start70,205,682 bp[1]
End70,253,052 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SRSF11
Genomic location for SRSF11
Band3|3 H4Start158,010,473 bp[2]
End158,036,639 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • visceral pleura

  • parietal pleura

  • tibia

  • mucosa of paranasal sinus

  • gastric mucosa

  • Achilles tendon

  • endothelial cell

  • skin of hip

  • sural nerve

  • germinal epithelium
Top expressed in
  • neural layer of retina

  • tail of embryo

  • genital tubercle

  • abdominal wall

  • cerebellar cortex

  • saccule

  • primitive streak

  • dermis

  • vas deferens

  • superior frontal gyrus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • nucleus
  • nucleoplasm
  • nuclear speck
Biological process
  • mRNA splicing, via spliceosome
  • termination of RNA polymerase II transcription
  • mRNA processing
  • mRNA 3'-end processing
  • mRNA export from nucleus
  • RNA splicing
  • RNA export from nucleus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9295

69207

Ensembl

ENSG00000116754

ENSMUSG00000055436

UniProt

Q05519
Q5T757

n/a

RefSeq (mRNA)
NM_001190987
NM_004768
NM_001350605
NM_001350606
NM_001350607

NM_001350608
NM_001350609
NM_001350610
NM_001350611
NM_001350612
NM_001350613
NM_001350614
NM_001350615
NM_001350616
NM_001394402
NM_001394403
NM_001394404
NM_001394405
NM_001394406
NM_001394407
NM_001394408

NM_001093752
NM_001093753
NM_026989
NM_001356997

RefSeq (protein)
NP_001177916
NP_004759
NP_001337534
NP_001337535
NP_001337536

NP_001337537
NP_001337538
NP_001337539
NP_001337540
NP_001337541
NP_001337542
NP_001337543
NP_001337544
NP_001337545

n/a

Location (UCSC)Chr 1: 70.21 – 70.25 MbChr 3: 158.01 – 158.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.[5][6]

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.[6]

Interactions

SFRS11 has been shown to interact with U2AF2.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116754 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055436 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi:10.1073/pnas.88.18.8189. PMC 52472. PMID 1896467.
  6. ^ a b "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".
  7. ^ Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10). UNITED STATES: 5400–8. doi:10.1128/MCB.16.10.5400. ISSN 0270-7306. PMC 231539. PMID 8816452.

Further reading

  • Zhang WJ; Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. PMC 231539. PMID 8816452.
  • Straub T, Grue P, Uhse A, et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". J. Biol. Chem. 273 (41): 26261–4. doi:10.1074/jbc.273.41.26261. PMID 9756848.
  • Page-McCaw PS; Amonlirdviman K; Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity". RNA. 5 (12): 1548–60. doi:10.1017/S1355838299991938. PMC 1369877. PMID 10606266.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
  • Wu JY, Kar A, Kuo D, et al. (2006). "SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy". Mol. Cell. Biol. 26 (18): 6739–47. doi:10.1128/MCB.00739-06. PMC 1592875. PMID 16943417.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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