SH3GLB2

Protein-coding gene in the species Homo sapiens
SH3GLB2
Identifiers
AliasesSH3GLB2, PP6569, PP9455, RRIG1, SH3 domain containing GRB2 like endophilin B2, SH3 domain containing GRB2 like, endophilin B2
External IDsOMIM: 609288; MGI: 2385131; HomoloGene: 10595; GeneCards: SH3GLB2; OMA:SH3GLB2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for SH3GLB2
Genomic location for SH3GLB2
Band9q34.11Start129,007,036 bp[1]
End129,028,331 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SH3GLB2
Genomic location for SH3GLB2
Band2|2 BStart30,234,821 bp[2]
End30,249,349 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • C1 segment

  • right frontal lobe

  • skin of abdomen

  • skin of leg

  • anterior cingulate cortex

  • right hemisphere of cerebellum

  • prefrontal cortex

  • body of stomach

  • right uterine tube
Top expressed in
  • superior frontal gyrus

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • cerebellar cortex

  • interventricular septum

  • transitional epithelium of urinary bladder

  • lip

  • neural layer of retina

  • central gray substance of midbrain

  • esophagus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • identical protein binding
  • cadherin binding
Cellular component
  • cytoplasm
  • nucleoplasm
  • cytosol
Biological process
  • cell-cell adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56904

227700

Ensembl

ENSG00000148341

ENSMUSG00000026860

UniProt

Q9NR46

Q8R3V5

RefSeq (mRNA)
NM_001287045
NM_001287046
NM_020145
NM_001369913
NM_001369914

NM_001369915

NM_001289709
NM_001289710
NM_139302
NM_001346806
NM_001362888

RefSeq (protein)
NP_001273974
NP_001273975
NP_064530
NP_001356842
NP_001356843

NP_001356844

NP_001276638
NP_001276639
NP_001333735
NP_647463
NP_001349817

Location (UCSC)Chr 9: 129.01 – 129.03 MbChr 2: 30.23 – 30.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Endophilin-B2 is a protein that in humans is encoded by the SH3GLB2 gene.[5][6]

Interactions

SH3GLB2 has been shown to interact with SH3GLB1[5] and SH3KBP1.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148341 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026860 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (February 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID 11161816.
  6. ^ "Entrez Gene: SH3GLB2 SH3-domain GRB2-like endophilin B2".
  7. ^ Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. Bibcode:2002Natur.416..187P. doi:10.1038/416187a. PMID 11894096. S2CID 4389099.
  8. ^ Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. PMID 11894095. S2CID 635702.

Further reading

  • Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
  • Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Mikula M, Dzwonek A, Karczmarski J, Rubel T, Dadlez M, Wyrwicz LS, Bomsztyk K, Ostrowski J (2006). "Landscape of the hnRNP K protein-protein interactome". Proteomics. 6 (8): 2395–406. doi:10.1002/pmic.200500632. PMID 16518874. S2CID 24395284.


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