SKAP2

Protein-coding gene in the species Homo sapiens

SKAP2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3OMH

Identifiers

Aliases

SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R, src kinase associated phosphoprotein 2

External IDs

OMIM: 605215; MGI: 1889206; HomoloGene: 2919; GeneCards: SKAP2; OMA:SKAP2 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7p15.2	Start	26,667,068 bp^[1]
Band	7p15.2	End	26,995,239 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 B3	Start	51,834,402 bp^[2]
Band	6\|6 B3	End	51,989,529 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sperm

secondary oocyte

pericardium

monocyte

trabecular bone

visceral pleura

buccal mucosa cell

bone marrow cells

lower lobe of lung

pylorus

Top expressed in

zygote

granulocyte

secondary oocyte

stroma of bone marrow

blood

primary oocyte

primitive streak

ascending aorta

mesenteric lymph nodes

renal corpuscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	plasma membrane cytoplasm nucleoplasm cytosol
Biological process	immune response-activating signal transduction B cell activation signal transduction negative regulation of cell population proliferation positive regulation of signal transduction protein-containing complex assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8935


54353

Ensembl


ENSG00000005020


ENSMUSG00000059182

UniProt


O75563


Q3UND0

RefSeq (mRNA)


NM_003930 NM_001303468


NM_018773

RefSeq (protein)


NP_001290397 NP_003921


NP_061243

Location (UCSC)

Chr 7: 26.67 – 27 Mb

Chr 6: 51.83 – 51.99 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in macrophages. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.^[7] It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal reorganization in macrophages.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005020 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059182 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T (November 1998). "RA70 is a src kinase-associated protein expressed ubiquitously". Biochemical and Biophysical Research Communications. 252 (3): 738–42. doi:10.1006/bbrc.1998.9637. PMID 9837776.
^ Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (September 1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Letters. 435 (1): 55–60. doi:10.1016/S0014-5793(98)01040-0. PMID 9755858. S2CID 37288744.
^ ^a ^b "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2".
^ Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD (November 2012). "Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement". Journal of Cell Science. 125 (Pt 22): 5535–45. doi:10.1242/jcs.111260. PMC 3561861. PMID 22976304.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (July 1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8779–84. Bibcode:1998PNAS...95.8779L. doi:10.1073/pnas.95.15.8779. PMC 21153. PMID 9671755.
Wang X, Stollar BD (November 1999). "Immunoglobulin VH gene expression in human aging". Clinical Immunology. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP (October 2000). "Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin". The Journal of Biological Chemistry. 275 (43): 33427–34. doi:10.1074/jbc.M001439200. PMID 10942756.
Curtis DJ, Jane SM, Hilton DJ, Dougherty L, Bodine DM, Begley CG (November 2000). "Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest". Experimental Hematology. 28 (11): 1250–9. doi:10.1016/S0301-472X(00)00537-3. PMID 11063873.
Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cavé-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G (June 2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". The Journal of Biological Chemistry. 276 (25): 22375–81. doi:10.1074/jbc.M011683200. PMID 11301322.
Kirchgessner H, Dietrich J, Scherer J, Isomäki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B (June 2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain". The Journal of Experimental Medicine. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
Takahashi T, Yamashita H, Nagano Y, Nakamura T, Ohmori H, Avraham H, Avraham S, Yasuda M, Matsumoto M (October 2003). "Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation". The Journal of Biological Chemistry. 278 (43): 42225–33. doi:10.1074/jbc.M213217200. PMID 12893833.
Park SY, Avraham HK, Avraham S (August 2004). "RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner". The Journal of Biological Chemistry. 279 (32): 33315–22. doi:10.1074/jbc.M313527200. PMID 15166227.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

PDB gallery

1u5e: Crystal Structure of a N-terminal Fragment of SKAP-Hom Containing Both the Helical Dimerization Domain and the PH Domain
1u5g: Crystal Structure of the PH Domain of SKAP-Hom
2otx: Crystal Structure of A N-terminal Fragment of SKAP-HOM Containing both the Helical Dimerization Domain and the PH Domain