SLAMF8

Protein-coding gene in humans
SLAMF8
Identifiers
AliasesSLAMF8, BLAME, CD353, SBBI42, SLAM family member 8
External IDsOMIM: 606620; MGI: 1921998; HomoloGene: 10589; GeneCards: SLAMF8; OMA:SLAMF8 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SLAMF8
Genomic location for SLAMF8
Band1q23.2Start159,826,811 bp[1]
End159,837,492 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for SLAMF8
Genomic location for SLAMF8
Band1|1 H3Start172,409,325 bp[2]
End172,418,135 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • appendix

  • lymph node

  • testicle

  • lower lobe of lung

  • decidua

  • spleen

  • superficial temporal artery

  • amniotic fluid

  • gallbladder

  • rectum
Top expressed in
  • mesenteric lymph nodes

  • embryo

  • spleen

  • lumbar subsegment of spinal cord

  • morula

  • granulocyte

  • right kidney

  • blastocyst

  • thymus

  • subcutaneous adipose tissue
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • signaling receptor activity
  • identical protein binding
Cellular component
  • membrane
  • integral component of membrane
  • cell surface
Biological process
  • leukocyte chemotaxis involved in inflammatory response
  • B-1 B cell lineage commitment
  • negative regulation of macrophage chemotaxis
  • regulation of NAD(P)H oxidase activity
  • defense response to bacterium
  • regulation of kinase activity
  • regulation of B cell differentiation
  • negative regulation of respiratory burst involved in inflammatory response
  • negative regulation of monocyte chemotaxis
  • phagosome acidification
  • negative regulation of neutrophil migration
  • negative regulation of dendritic cell chemotaxis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56833

74748

Ensembl

ENSG00000158714

ENSMUSG00000053318

UniProt

Q9P0V8

Q9D3G2

RefSeq (mRNA)

NM_020125
NM_001330741

NM_029084

RefSeq (protein)

NP_001317670
NP_064510

NP_083360

Location (UCSC)Chr 1: 159.83 – 159.84 MbChr 1: 172.41 – 172.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SLAM family member 8 is a protein that in humans is encoded by the SLAMF8 gene.[5][6]

Function

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158714 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053318 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kingsbury GA, Feeney LA, Nong Y, Calandra SA, Murphy CJ, Corcoran JM, Wang Y, Prabhu Das MR, Busfield SJ, Fraser CC, Villeval JL (May 2001). "Cloning, expression, and function of BLAME, a novel member of the CD2 family". Journal of Immunology. 166 (9): 5675–80. doi:10.4049/jimmunol.166.9.5675. PMID 11313408.
  6. ^ a b "Entrez Gene: SLAMF8 SLAM family member 8".

Further reading

  • Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (September 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.
  • Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
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