SNAP91

Protein-coding gene in the species Homo sapiens
SNAP91
Identifiers
AliasesSNAP91, AP180, CALM, synaptosome associated protein 91kDa, synaptosome associated protein 91
External IDsOMIM: 607923; MGI: 109132; HomoloGene: 8429; GeneCards: SNAP91; OMA:SNAP91 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SNAP91
Genomic location for SNAP91
Band6q14.2Start83,552,880 bp[1]
End83,709,691 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SNAP91
Genomic location for SNAP91
Band9|9 E3.1Start86,647,976 bp[2]
End86,762,707 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • Brodmann area 23

  • cerebellar vermis

  • endothelial cell

  • pons

  • lateral nuclear group of thalamus

  • superior frontal gyrus

  • orbitofrontal cortex

  • frontal pole

  • primary visual cortex
Top expressed in
  • pontine nuclei

  • medial dorsal nucleus

  • ventral tegmental area

  • medial vestibular nucleus

  • dorsal tegmental nucleus

  • anterior amygdaloid area

  • cerebellar vermis

  • lobe of cerebellum

  • dorsomedial hypothalamic nucleus

  • medial geniculate nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • clathrin binding
  • 1-phosphatidylinositol binding
  • protein binding
  • phospholipid binding
  • protein kinase binding
  • SNARE binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • clathrin heavy chain binding
Cellular component
  • plasma membrane
  • clathrin-coated pit
  • membrane
  • clathrin-coated vesicle
  • synaptic vesicle
  • presynaptic membrane
  • extrinsic component of presynaptic endocytic zone membrane
Biological process
  • clathrin coat assembly
  • protein transport
  • regulation of clathrin-dependent endocytosis
  • endocytosis
  • vesicle budding from membrane
  • synaptic vesicle budding from presynaptic endocytic zone membrane
  • synaptic vesicle endocytosis
  • clathrin-dependent endocytosis
  • chemical synaptic transmission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9892

20616

Ensembl

ENSG00000065609

ENSMUSG00000033419

UniProt

O60641

Q61548

RefSeq (mRNA)
NM_001242792
NM_001242793
NM_001242794
NM_001256717
NM_001256718

NM_014841
NM_001363677

NM_001277982
NM_001277983
NM_001277985
NM_001277986
NM_013669

NM_001357768
NM_001357770
NM_001357772

RefSeq (protein)
NP_001229721
NP_001229722
NP_001229723
NP_001243646
NP_001243647

NP_055656
NP_001350606
NP_001363604
NP_001363605
NP_001363606
NP_001363607
NP_001363608
NP_001363609
NP_001363610
NP_001363611
NP_001363612
NP_001363613
NP_001363614
NP_001363615
NP_001363616
NP_001363617
NP_001363618
NP_001363619
NP_001363620
NP_001363621
NP_001363622
NP_001363623
NP_001363624
NP_001363625
NP_001363626
NP_001363627
NP_001363628
NP_001363629
NP_001363630
NP_001363631
NP_001363632
NP_001363633
NP_001363634
NP_001363635
NP_001363636
NP_001363637
NP_001363638
NP_001363639
NP_001363640
NP_001363641
NP_001363642
NP_001363643
NP_001363644
NP_001363645
NP_001363646
NP_001363647
NP_001363648
NP_001363649
NP_001363650
NP_001363652
NP_001363655
NP_001363657
NP_001363660
NP_001363662
NP_001363663
NP_001363664
NP_001363665
NP_001363666
NP_001363667
NP_001363668
NP_001363669
NP_001363670
NP_001363671

NP_001264911
NP_001264912
NP_001264914
NP_001264915
NP_038697

NP_001344697
NP_001344699
NP_001344701

Location (UCSC)Chr 6: 83.55 – 83.71 MbChr 9: 86.65 – 86.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clathrin coat assembly protein AP180 is a protein that in humans is encoded by the SNAP91 gene.[5][6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065609 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033419 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ Yao PJ, O'Herron TM, Coleman PD (Dec 2002). "Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain". Neurobiology of Aging. 24 (1): 173–8. doi:10.1016/S0197-4580(02)00055-6. PMID 12493563. S2CID 35026098.
  7. ^ Tebar F, Bohlander SK, Sorkin A (August 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Molecular Biology of the Cell. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. PMC 25500. PMID 10436022.
  8. ^ "Entrez Gene: SNAP91 synaptosomal-associated protein, 91kDa homolog (mouse)".

Further reading

  • Murphy JE, Hanover JA, Froehlich M, DuBois G, Keen JH (August 1994). "Clathrin assembly protein AP-3 is phosphorylated and glycosylated on the 50-kDa structural domain". The Journal of Biological Chemistry. 269 (33): 21346–52. doi:10.1016/S0021-9258(17)31968-3. PMID 8063760.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Traub LM, Downs MA, Westrich JL, Fremont DH (August 1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proceedings of the National Academy of Sciences of the United States of America. 96 (16): 8907–12. Bibcode:1999PNAS...96.8907T. doi:10.1073/pnas.96.16.8907. PMC 17706. PMID 10430869.
  • Yao PJ, Morsch R, Callahan LM, Coleman PD (1999). "Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry". Neuroscience. 94 (2): 389–94. doi:10.1016/S0306-4522(99)00360-7. PMID 10579202. S2CID 24468341.
  • Slepnev VI, Ochoa GC, Butler MH, De Camilli P (June 2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites". The Journal of Biological Chemistry. 275 (23): 17583–9. doi:10.1074/jbc.M910430199. PMID 10748223.
  • Han SJ, Lee JH, Hong SH, Park SD, Kim CG, Song MD, Park TK, Kim CG (January 2002). "AP180 binds to the C-terminal SH2 domain of phospholipase C-gamma1 and inhibits its enzymatic activity". Biochemical and Biophysical Research Communications. 290 (1): 35–41. doi:10.1006/bbrc.2001.6154. PMID 11779129.
  • Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E (July 2003). "Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin". The Journal of Biological Chemistry. 278 (28): 25357–68. doi:10.1074/jbc.M303738200. PMID 12732633.
  • Hussain NK, Yamabhai M, Bhakar AL, Metzler M, Ferguson SS, Hayden MR, McPherson PS, Kay BK (August 2003). "A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding". The Journal of Biological Chemistry. 278 (31): 28823–30. doi:10.1074/jbc.M300995200. PMID 12750376.
  • Morgan JR, Prasad K, Jin S, Augustine GJ, Lafer EM (August 2003). "Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling". The Journal of Biological Chemistry. 278 (35): 33583–92. doi:10.1074/jbc.M304346200. PMID 12807910.
  • Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V (July 2003). "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma". The Journal of Cell Biology. 162 (1): 113–24. doi:10.1083/jcb.200301006. PMC 2172713. PMID 12847086.
  • Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Zhan X, Desiderio DM (December 2004). "The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry". Biochemical and Biophysical Research Communications. 325 (4): 1180–6. doi:10.1016/j.bbrc.2004.10.169. PMID 15555551.
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