SPSB1

Protein-coding gene in the species Homo sapiens
SPSB1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2JK9, 3F2O

Identifiers
AliasesSPSB1, SSB-1, SSB1, splA/ryanodine receptor domain and SOCS box containing 1
External IDsOMIM: 611657; MGI: 1921896; HomoloGene: 11832; GeneCards: SPSB1; OMA:SPSB1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SPSB1
Genomic location for SPSB1
Band1p36.22Start9,292,894 bp[1]
End9,369,532 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for SPSB1
Genomic location for SPSB1
Band4|4 E2Start149,980,740 bp[2]
End150,039,500 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • decidua

  • Descending thoracic aorta

  • ascending aorta

  • tibial arteries

  • gastric mucosa

  • saphenous vein

  • gallbladder

  • vena cava

  • right coronary artery

  • left coronary artery
Top expressed in
  • decidua

  • cumulus cell

  • gastrula

  • cardiac muscle tissue of left ventricle

  • molar

  • ascending aorta

  • epithelium of lens

  • aortic valve

  • tunica media of zone of aorta

  • ankle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ubiquitin-protein transferase activity
  • ubiquitin ligase-substrate adaptor activity
Cellular component
  • cytoplasm
  • cytosol
  • SCF ubiquitin ligase complex
Biological process
  • protein ubiquitination
  • protein polyubiquitination
  • post-translational protein modification
  • ubiquitin-dependent protein catabolic process
  • proteasome-mediated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80176

74646

Ensembl

ENSG00000171621

ENSMUSG00000039911

UniProt

Q96BD6

Q9D5L7

RefSeq (mRNA)

NM_025106

NM_029035

RefSeq (protein)

NP_079382

NP_083311

Location (UCSC)Chr 1: 9.29 – 9.37 MbChr 4: 149.98 – 150.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SPRY domain-containing SOCS box protein 1 is a protein that in humans is encoded by the SPSB1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171621 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039911 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang D, Li Z, Messing EM, Wu G (Apr 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". J Biol Chem. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.
  6. ^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  7. ^ "Entrez Gene: SPSB1 splA/ryanodine receptor domain and SOCS box containing 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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