STAP1

Protein-coding gene in the species Homo sapiens

STAP1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1X1F, 3MAZ

Identifiers

Aliases

STAP1, BRDG1, STAP-1, signal transducing adaptor family member 1

External IDs

OMIM: 604298; MGI: 1926193; HomoloGene: 8103; GeneCards: STAP1; OMA:STAP1 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.2	Start	67,558,727 bp^[1]
Band	4q13.2	End	67,607,337 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 E1	Start	86,219,605 bp^[2]
Band	5\|5 E1	End	86,253,984 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

lymph node

epithelium of nasopharynx

spleen

appendix

granulocyte

bone marrow cells

testicle

tonsil

superficial temporal artery

blood

Top expressed in

granulocyte

thymus

spleen

mesenteric lymph nodes

olfactory epithelium

blood

lumbar spinal ganglion

subcutaneous adipose tissue

tibiofemoral joint

lumbar subsegment of spinal cord

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	macrophage colony-stimulating factor receptor binding transmembrane receptor protein tyrosine kinase adaptor activity phosphotyrosine residue binding receptor tyrosine kinase binding protein binding phospholipid binding protein kinase binding signaling adaptor activity
Cellular component	cytoplasm mitochondrion nucleus nucleoplasm intracellular membrane-bounded organelle protein-containing complex
Biological process	positive regulation of B cell receptor signaling pathway positive regulation of phagocytosis, engulfment transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of ruffle assembly positive regulation of microglial cell mediated cytotoxicity positive regulation of non-membrane spanning protein tyrosine kinase activity negative regulation of microglial cell migration positive regulation of gene expression positive regulation of microglial cell activation negative regulation of phosphorylation cellular response to lipopolysaccharide negative regulation of macrophage colony-stimulating factor signaling pathway positive regulation of actin cytoskeleton reorganization negative regulation of macrophage chemotaxis response to bacterium
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


26228


56792

Ensembl


ENSG00000035720


ENSMUSG00000029254

UniProt


Q9ULZ2


Q9JM90

RefSeq (mRNA)


NM_012108 NM_001317769


NM_019992 NM_001310639

RefSeq (protein)


NP_001304698 NP_036240


NP_001297568 NP_064376

Location (UCSC)

Chr 4: 67.56 – 67.61 Mb

Chr 5: 86.22 – 86.25 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.^[7]

Interactions

STAP1 has been shown to interact with C19orf2.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000035720 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029254 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H (Nov 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proc Natl Acad Sci U S A. 96 (21): 11976–81. Bibcode:1999PNAS...9611976O. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561.
^ Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M (Mar 2000). "Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains". Biochem Biophys Res Commun. 268 (3): 697–703. doi:10.1006/bbrc.2000.2223. PMID 10679268.
^ ^a ^b "Entrez Gene: BRDG1 BCR downstream signaling 1".
^ Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (Nov 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.

Kurosaki T (1999). "Genetic analysis of B cell antigen receptor signaling". Annu. Rev. Immunol. 17 (1): 555–92. doi:10.1146/annurev.immunol.17.1.555. PMID 10358768.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Yokohari K, Yamashita Y, Okada S, Ohya K, Oda S, Hatano M, Mano H, Hirasawa H, Tokuhisa T (2002). "Isoform-dependent interaction of BRDG1 with Tec kinase". Biochem. Biophys. Res. Commun. 289 (2): 414–20. doi:10.1006/bbrc.2001.6008. PMID 11716489.
Minoguchi M, Minoguchi S, Aki D, Joo A, Yamamoto T, Yumioka T, Matsuda T, Yoshimura A (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif". J. Biol. Chem. 278 (13): 11182–9. doi:10.1074/jbc.M211230200. PMID 12540842.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.