STMN2

Protein-coding gene in the species Homo sapiens

STMN2

Identifiers

Aliases

STMN2, SCG10, SCGN10, stathmin 2

External IDs

OMIM: 600621; MGI: 98241; HomoloGene: 5102; GeneCards: STMN2; OMA:STMN2 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q21.13	Start	79,611,117 bp^[1]
Band	8q21.13	End	79,666,158 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3 A1\|3 2.15 cM	Start	8,574,420 bp^[2]
Band	3 A1\|3 2.15 cM	End	8,626,666 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pons

cerebellar vermis

spinal ganglia

lateral nuclear group of thalamus

ganglionic eminence

Pars compacta

superior vestibular nucleus

frontal pole

cerebellar hemisphere

paraflocculus of cerebellum

Top expressed in

superior cervical ganglion

barrel cortex

anterior horn of spinal cord

lobe of cerebellum

medial dorsal nucleus

facial motor nucleus

cerebellar vermis

cingulate gyrus

medulla oblongata

dentate gyrus of hippocampal formation granule cell

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium-dependent protein binding tubulin binding protein binding
Cellular component	cytoplasm vesicle endosome Golgi apparatus cell projection membrane growth cone axon neuronal cell body perinuclear region of cytoplasm neuron projection lamellipodium
Biological process	cellular response to nerve growth factor stimulus negative regulation of neuron projection development negative regulation of microtubule polymerization negative regulation of microtubule depolymerization regulation of microtubule polymerization or depolymerization positive regulation of neuron projection development positive regulation of microtubule depolymerization microtubule depolymerization neuron projection development regulation of cytoskeleton organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


11075


20257

Ensembl


ENSG00000104435


ENSMUSG00000027500

UniProt


Q93045


P55821

RefSeq (mRNA)


NM_001199214 NM_007029


NM_025285

RefSeq (protein)


NP_001186143 NP_008960


NP_079561

Location (UCSC)

Chr 8: 79.61 – 79.67 Mb

Chr 3: 8.57 – 8.63 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Stathmin-2 is a protein that in humans is encoded by the STMN2 gene.^[5]^[6]^[7]

Function

Superior cervical ganglion-10 is a neuronal growth-associated protein which shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM]^[7]

Interactions

STMN2 has been shown to interact with RGS6.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104435 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027500 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okazaki T, Wang H, Masliah E, Cao M, Johnson SA, Sundsmo M, Saitoh T, Mori N (June 1996). "SCG10, a neuron-specific growth-associated protein in Alzheimer's disease". Neurobiology of Aging. 16 (6): 883–94. doi:10.1016/0197-4580(95)02001-2. PMID 8622778. S2CID 54320124.
^ ^a ^b Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". The Journal of Biological Chemistry. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.
^ ^a ^b "Entrez Gene: STMN2 stathmin-like 2".

Di Paolo G, Lutjens R, Pellier V, Stimpson SA, Beuchat MH, Catsicas S, Grenningloh G (February 1997). "Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region". The Journal of Biological Chemistry. 272 (8): 5175–82. doi:10.1074/jbc.272.8.5175. PMID 9030585.
Antonsson B, Lütjens R, Di Paolo G, Kassel D, Allet B, Bernard A, Catsicas S, Grenningloh G (April 1997). "Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10". Protein Expression and Purification. 9 (3): 363–71. doi:10.1006/prep.1996.0710. PMID 9126608.
Antonsson B, Kassel DB, Di Paolo G, Lutjens R, Riederer BM, Grenningloh G (April 1998). "Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity". The Journal of Biological Chemistry. 273 (14): 8439–46. doi:10.1074/jbc.273.14.8439. PMID 9525956.
Lutjens R, Igarashi M, Pellier V, Blasey H, Di Paolo G, Ruchti E, Pfulg C, Staple JK, Catsicas S, Grenningloh G (July 2000). "Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles". The European Journal of Neuroscience. 12 (7): 2224–34. doi:10.1046/j.1460-9568.2000.00112.x. PMID 10947801. S2CID 41593815.
Neidhart S, Antonsson B, Gilliéron C, Vilbois F, Grenningloh G, Arkinstall S (November 2001). "c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10". FEBS Letters. 508 (2): 259–64. doi:10.1016/S0014-5793(01)03090-3. PMID 11718727. S2CID 84253949.
Nixon AB, Grenningloh G, Casey PJ (May 2002). "The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly". The Journal of Biological Chemistry. 277 (20): 18127–33. doi:10.1074/jbc.M201065200. PMID 11882662.
Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nature Neuroscience. 6 (8): 837–45. doi:10.1038/nn1092. PMID 12858178. S2CID 7523946.
Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH (March 2004). "A small modulatory dsRNA specifies the fate of adult neural stem cells". Cell. 116 (6): 779–93. doi:10.1016/S0092-8674(04)00248-X. PMID 15035981. S2CID 12656737.
Gocke CB, Yu H, Kang J (February 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". The Journal of Biological Chemistry. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lee HS, Lee DC, Park MH, Yang SJ, Lee JJ, Kim DM, Jang Y, Lee JH, Choi JY, Kang YK, Kim DI, Park KC, Kim SY, Yoo HS, Choi EJ, Yeom YI (July 2006). "STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells". Biochemical and Biophysical Research Communications. 345 (3): 1059–67. doi:10.1016/j.bbrc.2006.05.017. PMID 16712787.
Manna T, Grenningloh G, Miller HP, Wilson L (March 2007). "Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth". Biochemistry. 46 (11): 3543–52. doi:10.1021/bi061819d. PMID 17311410.