STOML2

Protein-coding gene in the species Homo sapiens
STOML2
Identifiers
AliasesSTOML2, SLP-2, HSPC108, stomatin like 2
External IDsOMIM: 608292; MGI: 1913842; HomoloGene: 8389; GeneCards: STOML2; OMA:STOML2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for STOML2
Genomic location for STOML2
Band9p13.3Start35,099,776 bp[1]
End35,103,195 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for STOML2
Genomic location for STOML2
Band4|4 A5Start43,027,690 bp[2]
End43,031,710 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • mucosa of transverse colon

  • right adrenal gland

  • right adrenal cortex

  • gastrocnemius muscle

  • left adrenal gland

  • left adrenal cortex

  • left ventricle

  • body of stomach

  • rectum
Top expressed in
  • epiblast

  • ventricular zone

  • neural tube

  • embryo

  • adrenal gland

  • embryo

  • proximal tubule

  • limb

  • quadriceps femoris muscle

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • cardiolipin binding
  • protein binding
  • GTPase binding
  • signaling receptor binding
  • lipid binding
Cellular component
  • cytoplasm
  • membrane
  • mitochondrial intermembrane space
  • plasma membrane
  • T cell receptor complex
  • mitochondrion
  • immunological synapse
  • actin cytoskeleton
  • membrane raft
  • COP9 signalosome
  • extrinsic component of plasma membrane
  • cytoskeleton
  • mitochondrial inner membrane
Biological process
  • CD4-positive, alpha-beta T cell activation
  • mitochondrial ATP synthesis coupled proton transport
  • mitochondrion organization
  • cellular calcium ion homeostasis
  • positive regulation of mitochondrial DNA replication
  • mitochondrial protein processing
  • lipid localization
  • protein complex oligomerization
  • stress-induced mitochondrial fusion
  • positive regulation of cardiolipin metabolic process
  • positive regulation of mitochondrial membrane potential
  • T cell receptor signaling pathway
  • interleukin-2 production
  • mitochondrial calcium ion transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

30968

66592

Ensembl

ENSG00000165283

ENSMUSG00000028455

UniProt

Q9UJZ1

Q99JB2

RefSeq (mRNA)

NM_013442
NM_001287031
NM_001287032
NM_001287033

NM_023231

RefSeq (protein)

NP_001273960
NP_001273961
NP_001273962
NP_038470

NP_075720

Location (UCSC)Chr 9: 35.1 – 35.1 MbChr 4: 43.03 – 43.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Stomatin-like protein 2 is a protein that in humans is encoded by the STOML2 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165283 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028455 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang Y, Morrow JS (Apr 2000). "Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues". J Biol Chem. 275 (11): 8062–71. doi:10.1074/jbc.275.11.8062. PMID 10713127.
  6. ^ Hajek P, Chomyn A, Attardi G (Feb 2007). "Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2" (PDF). J Biol Chem. 282 (8): 5670–81. doi:10.1074/jbc.M608168200. PMID 17121834. S2CID 2167533.
  7. ^ "Entrez Gene: STOML2 stomatin (EPB72)-like 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Owczarek CM, Treutlein HR, Portbury KJ, et al. (2001). "A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1". Cytogenet. Cell Genet. 92 (3–4): 196–203. doi:10.1159/000056902. PMID 11435687. S2CID 19349691.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
  • Zhang L, Ding F, Cao W, et al. (2006). "Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human esophageal squamous cell carcinoma". Clin. Cancer Res. 12 (5): 1639–46. doi:10.1158/1078-0432.CCR-05-1858. PMID 16533792.
  • John JP, Anrather D, Pollak A, Lubec G (2006). "Mass spectrometrical verification of stomatin-like protein 2 (SLP-2) primary structure". Proteins. 64 (2): 543–51. doi:10.1002/prot.20987. PMID 16671055. S2CID 24782924.
  • Cui Z, Zhang L, Hua Z, et al. (2007). "Stomatin-like protein 2 is overexpressed and related to cell growth in human endometrial adenocarcinoma". Oncol. Rep. 17 (4): 829–33. doi:10.3892/or.17.4.829. PMID 17342323.
  • Cao W, Zhang B, Liu Y, et al. (2007). "High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival". Am. J. Clin. Pathol. 128 (3): 430–6. doi:10.1309/C6X54HRB580EP2NQ. PMID 17709317.


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