Spermatogenesis associated 13

Protein-coding gene in the species Homo sapiens
SPATA13
Identifiers
AliasesSPATA13, ARHGEF29, ASEF2, spermatogenesis associated 13
External IDsOMIM: 613324; MGI: 104838; HomoloGene: 19482; GeneCards: SPATA13; OMA:SPATA13 - orthologs
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[1]
Chromosome 14 (mouse)
Genomic location for SPATA13
Genomic location for SPATA13
Band14 D1|14 31.77 cMStart60,871,450 bp[1]
End61,002,005 bp[1]
Gene ontology
Molecular function
  • protein binding
  • guanyl-nucleotide exchange factor activity
  • identical protein binding
Cellular component
  • cytoplasm
  • filopodium
  • ruffle membrane
  • plasma membrane
  • cell projection
  • membrane
  • lamellipodium
  • nucleoplasm
  • cytosol
Biological process
  • filopodium assembly
  • regulation of Rho protein signal transduction
  • regulation of cell migration
  • cell migration
  • lamellipodium assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

221178

219140

Ensembl

n/a

ENSMUSG00000021990

UniProt

Q96N96

Q5DU57

RefSeq (mRNA)
NM_001166271
NM_001286792
NM_001286793
NM_001286794
NM_001286795

NM_153023

NM_001033272
NM_001310594

RefSeq (protein)
NP_001159743
NP_001273721
NP_001273722
NP_001273723
NP_001273724

NP_694568
NP_694568.1

NP_001028444
NP_001297523
NP_001391878
NP_001391879
NP_001391880

NP_001391881
NP_001391882
NP_001391883
NP_001391893

Location (UCSC)n/aChr 14: 60.87 – 61 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Spermatogenesis associated 13 is a protein that in humans is encoded by the SPATA13 gene. [4]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021990 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: Spermatogenesis associated 13". Retrieved 2018-04-26.

Further reading

  • Kawasaki Y, Sagara M, Shibata Y, Shirouzu M, Yokoyama S, Akiyama T (December 2007). "Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42". Oncogene. 26 (55): 7620–267. doi:10.1038/sj.onc.1210574. PMID 17599059.
  • Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T (March 2009). "Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration". Oncogene. 28 (10): 1357–65. doi:10.1038/onc.2008.478. PMID 19151759.
  • Ding H, Xu Y, Bao X, Wang X, Cui G, Wang W, Hui R, Wang DW (January 2010). "Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke". Stroke. 41 (1): 177–80. doi:10.1161/STROKEAHA.109.567099. PMID 19910543.
  • Bristow JM, Sellers MH, Majumdar D, Anderson B, Hu L, Webb DJ (December 2009). "The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration". J. Cell Sci. 122 (Pt 24): 4535–46. doi:10.1242/jcs.053728. PMC 2787464. PMID 19934221.
  • Jean L, Majumdar D, Shi M, Hinkle LE, Diggins NL, Ao M, Broussard JA, Evans JC, Choma DP, Webb DJ (December 2013). "Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen". J. Cell Sci. 126 (Pt 24): 5585–97. doi:10.1242/jcs.131060. PMC 3860307. PMID 24144700.


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