TACC3

Protein-coding gene in the species Homo sapiens

TACC3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4LPZ, 4PKY

Identifiers

Aliases

TACC3, ERIC-1, ERIC1, transforming acidic coiled-coil containing protein 3, Tacc4, maskin

External IDs

OMIM: 605303; MGI: 1341163; HomoloGene: 81618; GeneCards: TACC3; OMA:TACC3 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4p16.3	Start	1,712,858 bp^[1]
Band	4p16.3	End	1,745,171 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 B2	Start	33,658,128 bp^[2]
Band	5\|5 B2	End	33,678,995 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

ventricular zone

secondary oocyte

right testis

left testis

granulocyte

monocyte

blood

ganglionic eminence

gonad

Top expressed in

primary oocyte

ventricular zone

yolk sac

epiblast

tail of embryo

primitive streak

spermatocyte

genital tubercle

maxillary prominence

embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	cytoplasm microtubule cytoskeleton spindle pole spindle cytoskeleton microtubule organizing center cytosol mitotic spindle
Biological process	cell population proliferation cerebral cortex development metaphase regulation of mitotic spindle organization microtubule cytoskeleton organization involved in mitosis cell cycle cell division microtubule cytoskeleton organization mitotic spindle organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10460


21335

Ensembl


ENSG00000013810


ENSMUSG00000037313

UniProt


Q9Y6A5


Q9JJ11

RefSeq (mRNA)


NM_006342


NM_001040435 NM_011524 NM_001310541

RefSeq (protein)


NP_006333


n/a

Location (UCSC)

Chr 4: 1.71 – 1.75 Mb

Chr 5: 33.66 – 33.68 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Transforming acidic coiled-coil-containing protein 3 is a protein that in humans is encoded by the TACC3 gene.^[5]^[6]

The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013810 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037313 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nurnberg B, Piekorz RP (Oct 2007). "The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival". J Biol Chem. 282 (40): 29273–83. doi:10.1074/jbc.M704151200. PMID 17675670.
^ ^a ^b "Entrez Gene: TACC3 transforming, acidic coiled-coil containing protein 3".

Lappin TR, Mullan RN, Stewart JP, et al. (2003). "AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains". Leuk. Lymphoma. 43 (7): 1455–9. doi:10.1080/1042819022386644. PMID 12389629. S2CID 2098614.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID 10366448.
Gergely F, Karlsson C, Still I, et al. (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi:10.1073/pnas.97.26.14352. PMC 18922. PMID 11121038.
McKeveney PJ, Hodges VM, Mullan RN, et al. (2001). "Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells". Br. J. Haematol. 112 (4): 1016–24. doi:10.1046/j.1365-2141.2001.02644.x. PMID 11298601. S2CID 27869385.
Piekorz RP, Hoffmeyer A, Duntsch CD, et al. (2002). "The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis". EMBO J. 21 (4): 653–64. doi:10.1093/emboj/21.4.653. PMC 125348. PMID 11847113.
Steadman BT, Schmidt PH, Shanks RA, et al. (2002). "Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus". J. Biol. Chem. 277 (33): 30165–76. doi:10.1074/jbc.M201914200. PMID 12015314.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sadek CM, Pelto-Huikko M, Tujague M, et al. (2004). "TACC3 expression is tightly regulated during early differentiation". Gene Expr. Patterns. 3 (2): 203–11. doi:10.1016/S1567-133X(02)00066-2. PMID 12711550.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Gangisetty O, Lauffart B, Sondarva GV, et al. (2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene. 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476. S2CID 22590391.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.