TAF3

Protein-coding gene in the species Homo sapiens
TAF3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5C13

Identifiers
AliasesTAF3, TAF140, TAFII-140, TAFII140, TATA-box binding protein associated factor 3
External IDsOMIM: 606576; MGI: 2388097; HomoloGene: 35415; GeneCards: TAF3; OMA:TAF3 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for TAF3
Genomic location for TAF3
Band10p14Start7,818,497 bp[1]
End8,016,631 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for TAF3
Genomic location for TAF3
Band2|2 A1Start9,919,363 bp[2]
End10,053,407 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • vena cava

  • oocyte

  • cardia

  • sural nerve

  • secondary oocyte

  • internal globus pallidus

  • pylorus

  • pericardium

  • ventral tegmental area
Top expressed in
  • zygote

  • primary oocyte

  • secondary oocyte

  • genital tubercle

  • otolith organ

  • utricle

  • tail of embryo

  • substantia nigra

  • hand

  • retinal pigment epithelium
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • p53 binding
  • protein binding
  • metal ion binding
  • protein heterodimerization activity
Cellular component
  • nucleus
  • nucleoplasm
  • nuclear membrane
  • transcription factor TFIID complex
Biological process
  • transcription initiation from RNA polymerase II promoter
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • negative regulation of DNA-binding transcription factor activity
  • maintenance of protein location in nucleus
  • transcription, DNA-templated
  • regulation of signal transduction by p53 class mediator
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83860

209361

Ensembl

ENSG00000165632

ENSMUSG00000025782

UniProt

Q5VWG9

Q5HZG4

RefSeq (mRNA)

NM_031923

NM_027748

RefSeq (protein)

NP_114129

NP_082024

Location (UCSC)Chr 10: 7.82 – 8.02 MbChr 2: 9.92 – 10.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription initiation factor TFIID subunit 3 is a protein that in humans is encoded by the TAF3 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165632 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025782 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gangloff YG, Pointud JC, Thuault S, Carre L, Romier C, Muratoglu S, Brand M, Tora L, Couderc JL, Davidson I (Jul 2001). "The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger". Mol Cell Biol. 21 (15): 5109–21. doi:10.1128/MCB.21.15.5109-5121.2001. PMC 87236. PMID 11438666.
  6. ^ Bereczki O, Ujfaludi Z, Pardi N, Nagy Z, Tora L, Boros IM, Balint E (Jun 2008). "TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function". BMC Mol Biol. 9: 57. doi:10.1186/1471-2199-9-57. PMC 2441632. PMID 18549481.
  7. ^ "Entrez Gene: TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Soutoglou E, Demény MA, Scheer E, et al. (2005). "The Nuclear Import of TAF10 Is Regulated by One of Its Three Histone Fold Domain-Containing Interaction Partners". Mol. Cell. Biol. 25 (10): 4092–104. doi:10.1128/MCB.25.10.4092-4104.2005. PMC 1087738. PMID 15870280.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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