TAF4B

Protein-coding gene in the species Homo sapiens
TAF4B
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1H3O, 2P6V

Identifiers
AliasesTAF4B, SPGF13, TAF2C2, TAFII105, TATA-box binding protein associated factor 4b
External IDsOMIM: 601689; MGI: 2152345; HomoloGene: 28266; GeneCards: TAF4B; OMA:TAF4B - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for TAF4B
Genomic location for TAF4B
Band18q11.2Start26,226,445 bp[1]
End26,391,685 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for TAF4B
Genomic location for TAF4B
Band18|18 A1Start14,916,302 bp[2]
End15,033,416 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • buccal mucosa cell

  • gonad

  • testicle

  • Brodmann area 23

  • endothelial cell

  • middle temporal gyrus

  • cartilage tissue

  • Achilles tendon

  • tibialis anterior muscle
Top expressed in
  • Epithelium of choroid plexus

  • lumbar spinal ganglion

  • hand

  • Gonadal ridge

  • otolith organ

  • utricle

  • Paneth cell

  • cumulus cell

  • oocyte

  • secondary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • NF-kappaB binding
  • protein heterodimerization activity
  • transcription coactivator activity
  • transcription factor binding
  • RNA polymerase II general transcription initiation factor activity
Cellular component
  • cytoplasm
  • nucleus
  • nucleoplasm
  • fibrillar center
  • transcription factor TFIID complex
Biological process
  • DNA-templated transcription, initiation
  • cell differentiation
  • transcription initiation from RNA polymerase II promoter
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • spermatogenesis
  • transcription, DNA-templated
  • oogenesis
  • regulation of signal transduction by p53 class mediator
  • positive regulation of transcription by RNA polymerase II
  • RNA polymerase II preinitiation complex assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6875

72504

Ensembl

ENSG00000141384

ENSMUSG00000054321

UniProt

Q92750

G5E8Z2

RefSeq (mRNA)

NM_001293725
NM_005640

NM_001100449
NM_001369357
NM_001369358

RefSeq (protein)

NP_001280654
NP_005631

NP_001093919
NP_001356286
NP_001356287

Location (UCSC)Chr 18: 26.23 – 26.39 MbChr 18: 14.92 – 15.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.[5][6][7]

Function

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM][7]

Interactions

TAF4B has been shown to interact with RELA.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141384 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054321 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell. 87 (1): 137–46. doi:10.1016/S0092-8674(00)81330-6. PMID 8858156. S2CID 10194253.
  6. ^ Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi:10.1074/jbc.275.24.18180. PMID 10849440.
  7. ^ a b "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".
  8. ^ Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

Further reading

  • Liu WL, Coleman RA, Grob P, King DS, Florens L, Washburn MP, Geles KG, Yang JL, Ramey V, Nogales E, Tjian R (2008). "Structural changes in TAF4b-TFIID correlate with promoter selectivity". Mol. Cell. 29 (1): 81–91. doi:10.1016/j.molcel.2007.11.003. PMC 2486835. PMID 18206971.
  • Wu Y, Lu Y, Hu Y, Li R (2005). "Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line". J. Cell. Biochem. 96 (4): 751–9. doi:10.1002/jcb.20577. PMID 16088961. S2CID 23658728.
  • Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R (2005). "Core promoter binding by histone-like TAF complexes". Mol. Cell. Biol. 25 (1): 206–19. doi:10.1128/MCB.25.1.206-219.2005. PMC 538770. PMID 15601843.
  • Rashevsky-Finkel A, Silkov A, Dikstein R (2001). "A composite nuclear export signal in the TBP-associated factor TAFII105". J. Biol. Chem. 276 (48): 44963–9. doi:10.1074/jbc.M106112200. PMID 11567023.
  • Wolstein O, Silkov A, Revach M, Dikstein R (2000). "Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription". J. Biol. Chem. 275 (22): 16459–65. doi:10.1074/jbc.275.22.16459. PMID 10828057.
  • Yamit-Hezi A, Dikstein R (1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.


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