TCP11

Protein-coding gene in the species Homo sapiens
TCP11
Identifiers
AliasesTCP11, D6S230E, FPPR, t-complex 11
External IDsOMIM: 186982; MGI: 98544; HomoloGene: 8433; GeneCards: TCP11; OMA:TCP11 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TCP11
Genomic location for TCP11
Band6p21.31Start35,118,071 bp[1]
End35,148,610 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for TCP11
Genomic location for TCP11
Band17 A3.3|17 14.62 cMStart28,066,745 bp[2]
End28,080,639 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • left testis

  • right testis

  • testicle

  • gonad

  • oocyte

  • secondary oocyte

  • right uterine tube

  • olfactory zone of nasal mucosa

  • amniotic fluid
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • lens

  • epithelium of lens

  • neural layer of retina

  • motor neuron

  • molar

  • embryo

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • membrane
  • acrosomal vesicle
  • cytoplasmic vesicle
  • sperm flagellum
  • cell projection
  • sperm midpiece
  • motile cilium
  • cilium
Biological process
  • cell differentiation
  • spermatogenesis
  • multicellular organism development
  • protein kinase A signaling
  • regulation of cAMP-mediated signaling
  • regulation of sperm capacitation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6954

21463

Ensembl

ENSG00000124678

ENSMUSG00000062859

UniProt

Q8WWU5

Q01755

RefSeq (mRNA)
NM_001093728
NM_001261817
NM_001261818
NM_001261819
NM_001261820

NM_001261821
NM_018679

NM_001085555
NM_013687
NM_001357681
NM_001374620
NM_001374621

RefSeq (protein)
NP_001248746
NP_001248747
NP_001248748
NP_001248749
NP_001248750

NP_061149
NP_001353252
NP_001353253
NP_001353254
NP_001353255
NP_001353256
NP_001353257
NP_001353258
NP_001353259
NP_001353260
NP_001353261
NP_001357616

n/a

Location (UCSC)Chr 6: 35.12 – 35.15 MbChr 17: 28.07 – 28.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-complex protein 11 homolog is a protein that in humans is encoded by the TCP11 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124678 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062859 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ragoussis J, Senger G, Mockridge I, Sanseau P, Ruddy S, Dudley K, Sheer D, Trowsdale J (Nov 1992). "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11". Genomics. 14 (3): 673–9. doi:10.1016/S0888-7543(05)80167-3. PMID 1427894.
  6. ^ Ma Y, Zhang S, Xia Q, Zhang G, Huang X, Huang M, Xiao C, Pan A, Sun Y, Lebo R, Milunsky A (Jan 2002). "Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide". Molecular Human Reproduction. 8 (1): 24–31. doi:10.1093/molehr/8.1.24. PMID 11756566.
  7. ^ "Entrez Gene: TCP11 t-complex 11 (mouse)".

Further reading

  • Ma YX, Zhang SZ, Wu QQ, Sun Y, Qiu WM, Xu WM (Apr 2003). "[Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 25 (2): 122–8. PMID 12905703.
  • Ma YX, Zhang SZ, Wu QQ, Sun Y (Feb 2003). "[Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 35 (2): 182–8. PMID 12545228.
  • Fraser LR, Hosseini R, Hanyalogou A, Talmor A, Dudley RK (Nov 1997). "TCP-11, the product of a mouse t-complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction". Molecular Reproduction and Development. 48 (3): 375–82. doi:10.1002/(SICI)1098-2795(199711)48:3<375::AID-MRD11>3.0.CO;2-V. PMID 9322250. S2CID 42009443.
  • Mazarakis ND, Nelki D, Lyon MF, Ruddy S, Evans EP, Freemont P, Dudley K (Feb 1991). "Isolation and characterisation of a testis-expressed developmentally regulated gene from the distal inversion of the mouse t-complex". Development. 111 (2): 561–71. doi:10.1242/dev.111.2.561. PMID 1893875.


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