TEX10

Protein-coding gene in the species Homo sapiens
TEX10
Identifiers
AliasesTEX10, Ipi1, bA208F1.2, testis expressed 10
External IDsOMIM: 616717; MGI: 1344413; HomoloGene: 32361; GeneCards: TEX10; OMA:TEX10 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for TEX10
Genomic location for TEX10
Band9q31.1Start100,302,077 bp[1]
End100,352,942 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for TEX10
Genomic location for TEX10
Band4|4 B1Start48,430,858 bp[2]
End48,473,459 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • gonad

  • ganglionic eminence

  • testicle

  • sperm

  • Achilles tendon

  • cartilage tissue

  • endothelial cell

  • gastrocnemius muscle

  • right testis
Top expressed in
  • primitive streak

  • Gonadal ridge

  • internal carotid artery

  • external carotid artery

  • abdominal wall

  • transitional epithelium of urinary bladder

  • ureter

  • ectoderm

  • otic vesicle

  • otic placode
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • MLL1 complex
  • nucleolus
  • nucleus
  • Rix1 complex
  • nucleoplasm
Biological process
  • rRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54881

269536

Ensembl

ENSG00000136891

ENSMUSG00000028345

UniProt

Q9NXF1

Q3URQ0

RefSeq (mRNA)

NM_001161584
NM_017746

NM_172304
NM_001355740
NM_001355741

RefSeq (protein)

NP_001155056
NP_060216
NP_060216.2

NP_758508
NP_001342669
NP_001342670

Location (UCSC)Chr 9: 100.3 – 100.35 MbChr 4: 48.43 – 48.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Testis-expressed sequence 10 protein is a protein that in humans is encoded by the TEX10 gene.[5][6]

TEX10 forms part of a complex with WDR18, LAS1L called the rixosome that participates in RNA degradation, ribosomal RNA (rRNA) processing and ribosome biogenesis.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136891 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028345 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: TEX10 testis expressed sequence 10".
  7. ^ Castle CD, Cassimere EK, Denicourt C (February 2012). "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell. 23 (4): 716–728. doi:10.1091/mbc.E11-06-0530. PMC 3279398. PMID 22190735.

[1]

Further reading

  • Ohira M, Morohashi A, Nakamura Y, Isogai E, Furuya K, Hamano S, et al. (July 2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Letters. 197 (1–2): 63–68. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
  • Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, et al. (October 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–7745. doi:10.1038/sj.onc.1207921. PMID 15334068.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, et al. (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–4109. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.


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  1. ^ Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020). "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife. 9. doi:10.7554/eLife.54341. PMC 7269676. PMID 32491985.