TFDP2

Protein-coding gene in the species Homo sapiens
TFDP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1CF7

Identifiers
AliasesTFDP2, DP2, transcription factor Dp-2
External IDsOMIM: 602160; MGI: 107167; HomoloGene: 4578; GeneCards: TFDP2; OMA:TFDP2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for TFDP2
Genomic location for TFDP2
Band3q23Start141,944,428 bp[1]
End142,149,544 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for TFDP2
Genomic location for TFDP2
Band9|9 E3.3Start96,196,275 bp[2]
End96,323,646 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • left testis

  • right testis

  • ventricular zone

  • bone marrow cells

  • thymus

  • ganglionic eminence

  • gonad

  • epithelium of colon

  • olfactory zone of nasal mucosa
Top expressed in
  • blood

  • otic vesicle

  • myocardium of ventricle

  • tibialis anterior muscle

  • interventricular septum

  • hand

  • tail of embryo

  • vastus lateralis muscle

  • genital tubercle

  • Epithelium of choroid plexus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • transcription factor binding
  • protein binding
  • transcription coregulator activity
  • protein domain specific binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • transcription regulator complex
  • nucleoplasm
  • mitochondrion
  • RNA polymerase II transcription regulator complex
Biological process
  • regulation of transcription by RNA polymerase II
  • cell cycle
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • mitotic cell cycle
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • heart development
  • transcription, DNA-templated
  • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  • regulation of transcription involved in G1/S transition of mitotic cell cycle
  • transcription by RNA polymerase II
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of G0 to G1 transition
  • regulation of cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7029

211586

Ensembl

ENSG00000114126

ENSMUSG00000032411

UniProt

Q14188

Q64163

RefSeq (mRNA)
NM_001178138
NM_001178139
NM_001178140
NM_001178141
NM_001178142

NM_006286
NM_001375756
NM_001375773
NM_001375774
NM_001375775
NM_001375776
NM_001375778
NM_001375779
NM_001375780

NM_001184706
NM_001184708
NM_001184709
NM_001184710
NM_001184711

NM_178667

RefSeq (protein)
NP_001171609
NP_001171610
NP_001171611
NP_001171612
NP_001171613

NP_006277
NP_001362685
NP_001362702
NP_001362703
NP_001362704
NP_001362705
NP_001362707
NP_001362708
NP_001362709

n/a

Location (UCSC)Chr 3: 141.94 – 142.15 MbChr 9: 96.2 – 96.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in the regulation of the cell cycle.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114126 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032411 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang Y, Chellappan SP (Jul 1995). "Cloning and characterization of human DP2, a novel dimerization partner of E2F". Oncogene. 10 (11): 2085–93. PMID 7784053.
  6. ^ Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics. 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID 9027491.
  7. ^ "Entrez Gene: TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)".

Further reading

  • Wu CL, Zukerberg LR, Ngwu C, et al. (1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC 230484. PMID 7739537.
  • Rogers KT, Higgins PD, Milla MM, et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. Bibcode:1996PNAS...93.7594R. doi:10.1073/pnas.93.15.7594. PMC 38791. PMID 8755520.
  • Loiseau L, Pasteau S, Brun G (1998). "Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor". Gene Expr. 6 (5): 259–73. PMC 6148286. PMID 9368098.
  • Trimarchi JM, Fairchild B, Verona R, et al. (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. Bibcode:1998PNAS...95.2850T. doi:10.1073/pnas.95.6.2850. PMC 19658. PMID 9501179.
  • Gaubatz S, Wood JG, Livingston DM (1998). "Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9190–5. Bibcode:1998PNAS...95.9190G. doi:10.1073/pnas.95.16.9190. PMC 21314. PMID 9689056.
  • Zheng N, Fraenkel E, Pabo CO, Pavletich NP (1999). "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F–DP". Genes Dev. 13 (6): 666–74. doi:10.1101/gad.13.6.666. PMC 316551. PMID 10090723.
  • Korz C, Pscherer A, Benner A, et al. (2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood. 99 (12): 4554–61. doi:10.1182/blood.V99.12.4554. PMID 12036888.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Park KK, Deok Ahn J, Lee IK, et al. (2003). "Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP". Biochem. Biophys. Res. Commun. 308 (4): 689–97. doi:10.1016/S0006-291X(03)01455-4. PMID 12927774.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Overview of all the structural information available in the PDB for UniProt: Q14188 (Transcription factor Dp-2) at the PDBe-KB.
  • v
  • t
  • e
  • 1cf7: STRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP
    1cf7: STRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP


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