THYN1

Protein-coding gene in the species Homo sapiens
THYN1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3EOP, 5J3E

Identifiers
AliasesTHYN1, MDS012, MY105, THY28, THY28KD, HSPC144, thymocyte nuclear protein 1
External IDsOMIM: 613739; MGI: 1925112; HomoloGene: 8575; GeneCards: THYN1; OMA:THYN1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for THYN1
Genomic location for THYN1
Band11q25Start134,248,279 bp[1]
End134,253,370 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for THYN1
Genomic location for THYN1
Band9|9 A4Start26,911,006 bp[2]
End26,918,632 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • right hemisphere of cerebellum

  • right frontal lobe

  • anterior pituitary

  • Brodmann area 9

  • left ovary

  • nucleus accumbens

  • anterior cingulate cortex

  • ganglionic eminence

  • right ovary
Top expressed in
  • genital tubercle

  • embryo

  • tail of embryo

  • ventricular zone

  • embryo

  • neural layer of retina

  • endocardial cushion

  • Epithelium of choroid plexus

  • spermatocyte

  • cerebellar cortex
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

29087

77862

Ensembl

ENSG00000151500

ENSMUSG00000035443

UniProt

Q9P016

Q91YJ3

RefSeq (mRNA)

NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298

NM_144543
NM_001326361

RefSeq (protein)

NP_001032381
NP_001032382
NP_054893
NP_954994
NP_954995

NP_001313290
NP_653126

Location (UCSC)Chr 11: 134.25 – 134.25 MbChr 9: 26.91 – 26.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thymocyte nuclear protein 1 is a protein that in humans is encoded by the THYN1 gene.[5][6][7]

This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151500 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035443 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jiang XZ, Toyota H, Yoshimoto T, Takada E, Asakura H, Mizuguchi J (Nov 2003). "Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells". Apoptosis. 8 (5): 509–19. doi:10.1023/A:1025594409056. PMID 14601557. S2CID 2092518.
  6. ^ Miyaji H, Yoshimoto T, Asakura H, Komachi A, Kamiya S, Takasaki M, Mizuguchi J (Oct 2002). "Molecular cloning and characterization of the mouse thymocyte protein gene". Gene. 297 (1–2): 189–96. doi:10.1016/S0378-1119(02)00886-7. PMID 12384300.
  7. ^ a b "Entrez Gene: THYN1 thymocyte nuclear protein 1".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jiang X, Toyota H, Takada E, et al. (2004). "Modulation of mThy28 nuclear protein expression during thymocyte development". Tissue & Cell. 35 (6): 471–8. doi:10.1016/S0040-8166(03)00073-9. PMID 14580360.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Song AX, Chang YG, Gao YG, et al. (2005). "Identification, expression, and purification of a unique stable domain from human HSPC144 protein". Protein Expr. Purif. 42 (1): 146–52. doi:10.1016/j.pep.2005.03.008. PMID 15939300.


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