TIPIN

Protein-coding gene in the species Homo sapiens
TIPIN
Identifiers
AliasesTIPIN, TIMELESS interacting protein
External IDsOMIM: 610716; MGI: 1921571; HomoloGene: 32373; GeneCards: TIPIN; OMA:TIPIN - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for TIPIN
Genomic location for TIPIN
Band15q22.31Start66,336,191 bp[1]
End66,386,746 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for TIPIN
Genomic location for TIPIN
Band9 C|9 34.6 cMStart64,188,863 bp[2]
End64,212,706 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • testicle

  • Achilles tendon

  • secondary oocyte

  • right testis

  • left testis

  • ganglionic eminence

  • ventricular zone

  • islet of Langerhans

  • sperm
Top expressed in
  • fetal liver hematopoietic progenitor cell

  • medial ganglionic eminence

  • mandibular prominence

  • otic placode

  • abdominal wall

  • embryo

  • maxillary prominence

  • somite

  • primitive streak

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • DNA binding
Cellular component
  • intracellular membrane-bounded organelle
  • nucleus
  • nucleoplasm
  • cytoplasm
  • replication fork protection complex
Biological process
  • cell cycle phase transition
  • mitotic intra-S DNA damage checkpoint signaling
  • cellular response to DNA damage stimulus
  • cell division
  • DNA replication checkpoint signaling
  • regulation of nuclear cell cycle DNA replication
  • positive regulation of cell population proliferation
  • cell cycle
  • replication fork arrest
  • replication fork protection
  • DNA damage checkpoint signaling
  • response to UV
  • DNA replication
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54962

66131

Ensembl

ENSG00000075131

ENSMUSG00000032397

UniProt

Q9BVW5

Q91WA1

RefSeq (mRNA)
NM_001289986
NM_017858
NM_001398281
NM_001398282
NM_001398283

NM_001398284
NM_001398285
NM_001398286
NM_001398287

NM_025372
NM_001324556
NM_001324557
NM_001324558

RefSeq (protein)

NP_001276915
NP_060328

NP_001311485
NP_001311486
NP_001311487
NP_079648

Location (UCSC)Chr 15: 66.34 – 66.39 MbChr 9: 64.19 – 64.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene.[5][6][7]

Interactions

TIPIN has been shown to interact with Replication protein A1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075131 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032397 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gotter AL (Aug 2003). "Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association". Journal of Molecular Biology. 331 (1): 167–76. doi:10.1016/S0022-2836(03)00633-8. PMID 12875843.
  6. ^ Yoshizawa-Sugata N, Masai H (Jan 2007). "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint". The Journal of Biological Chemistry. 282 (4): 2729–40. doi:10.1074/jbc.M605596200. PMID 17102137.
  7. ^ "Entrez Gene: TIPIN TIMELESS interacting protein".
  8. ^ Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.

Further reading

  • Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.
  • Gotter AL, Suppa C, Emanuel BS (Feb 2007). "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors". Journal of Molecular Biology. 366 (1): 36–52. doi:10.1016/j.jmb.2006.10.097. PMC 4151250. PMID 17141802.
  • Chou DM, Elledge SJ (Nov 2006). "Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18143–7. Bibcode:2006PNAS..10318143C. doi:10.1073/pnas.0609251103. PMC 1654129. PMID 17116885.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
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