TJAP1

Protein-coding gene in the species Homo sapiens
TJAP1
Identifiers
AliasesTJAP1, PILT, TJP4, tight junction associated protein 1
External IDsOMIM: 612658; MGI: 1921344; HomoloGene: 12534; GeneCards: TJAP1; OMA:TJAP1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TJAP1
Genomic location for TJAP1
Band6p21.1Start43,477,523 bp[1]
End43,506,556 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for TJAP1
Genomic location for TJAP1
Band17|17 CStart46,568,777 bp[2]
End46,593,952 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • sural nerve

  • C1 segment

  • inferior ganglion of vagus nerve

  • optic nerve

  • inferior olivary nucleus

  • left ovary

  • gastrocnemius muscle

  • right ovary

  • body of uterus
Top expressed in
  • muscle of thigh

  • ventricular zone

  • neural layer of retina

  • lip

  • vestibular sensory epithelium

  • zygote

  • gastrula

  • yolk sac

  • primary visual cortex

  • epiblast
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • cell junction
  • endosome
  • trans-Golgi network
  • plasma membrane
  • bicellular tight junction
  • Golgi apparatus
Biological process
  • Golgi organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

93643

74094

Ensembl

ENSG00000137221

ENSMUSG00000012296

UniProt

Q5JTD0

Q9DCD5

RefSeq (mRNA)
NM_001146016
NM_001146017
NM_001146018
NM_001146019
NM_001146020

NM_080604
NM_001350561
NM_001350562
NM_001350563
NM_001350564
NM_001350565
NM_001350566
NM_001350567
NM_001350568
NM_001350569
NM_001350570
NM_001394538
NM_001394539
NM_001394540
NM_001394541
NM_001394542
NM_001394543
NM_001394544
NM_001394545

NM_001252473
NM_001252474
NM_001252475
NM_028751

RefSeq (protein)
NP_001139488
NP_001139489
NP_001139490
NP_001139491
NP_001139492

NP_542171
NP_001337490
NP_001337491
NP_001337492
NP_001337493
NP_001337494
NP_001337495
NP_001337496
NP_001337497
NP_001337498
NP_001337499

NP_001239402
NP_001239403
NP_001239404
NP_083027

Location (UCSC)Chr 6: 43.48 – 43.51 MbChr 17: 46.57 – 46.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tight junction-associated protein 1 is a protein that in humans is encoded by the TJAP1 gene.[5][6]


Interactions

TJAP1 has been shown to interact with DLG1.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137221 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000012296 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Kawabe H, Nakanishi H, Asada M, Fukuhara A, Morimoto K, Takeuchi M, Takai Y (Dec 2001). "Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells". J Biol Chem. 276 (51): 48350–5. doi:10.1074/jbc.M107335200. PMID 11602598.
  6. ^ "Entrez Gene: TJAP1 tight junction associated protein 1 (peripheral)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Xavier R, Rabizadeh S, Ishiguro K, et al. (2004). "Discs large (Dlg1) complexes in lymphocyte activation". J. Cell Biol. 166 (2): 173–8. doi:10.1083/jcb.200309044. PMC 2172307. PMID 15263016.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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