TMEM117

Protein-coding gene in the species Homo sapiens
TMEM117
Identifiers
AliasesTMEM117, transmembrane protein 117
External IDsMGI: 2444580; HomoloGene: 12992; GeneCards: TMEM117; OMA:TMEM117 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for TMEM117
Genomic location for TMEM117
Band12q12Start43,835,967 bp[1]
End44,389,762 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for TMEM117
Genomic location for TMEM117
Band15|15 E3Start94,527,113 bp[2]
End94,993,979 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cardiac muscle tissue of right atrium

  • myocardium of left ventricle

  • human penis

  • skin of arm

  • pancreatic epithelial cell

  • trigeminal ganglion

  • mucosa of paranasal sinus

  • testicle

  • spinal ganglia

  • stromal cell of endometrium
Top expressed in
  • otolith organ

  • utricle

  • vestibular sensory epithelium

  • olfactory epithelium

  • zygote

  • secondary oocyte

  • stria vascularis

  • soleus muscle

  • lacrimal gland

  • primary oocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • molecular function
Cellular component
  • endoplasmic reticulum
  • integral component of membrane
  • membrane
  • plasma membrane
Biological process
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84216

320709

Ensembl

ENSG00000139173

ENSMUSG00000063296

UniProt

Q9H0C3

Q8BH18

RefSeq (mRNA)

NM_001286211
NM_001286212
NM_001286213
NM_032256

NM_178789

RefSeq (protein)

NP_001273140
NP_001273141
NP_001273142
NP_115632

NP_848904

Location (UCSC)Chr 12: 43.84 – 44.39 MbChr 15: 94.53 – 94.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane protein 117 is a protein that in humans is encoded by the TMEM117 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139173 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063296 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ "Entrez Gene: TMEM117 transmembrane protein 117".

Further reading

  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.


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