TRAM2

Protein-coding gene in the species Homo sapiens
TRAM2
Identifiers
AliasesTRAM2, translocation associated membrane protein 2
External IDsOMIM: 608485; MGI: 1924817; HomoloGene: 8183; GeneCards: TRAM2; OMA:TRAM2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TRAM2
Genomic location for TRAM2
Band6p12.2Start52,497,408 bp[1]
End52,577,060 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for TRAM2
Genomic location for TRAM2
Band1|1 A4Start21,066,523 bp[2]
End21,149,453 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • stromal cell of endometrium

  • placenta

  • cartilage tissue

  • tibia

  • synovial membrane

  • synovial joint

  • mucosa of ileum

  • visceral pleura
Top expressed in
  • ascending aorta

  • aortic valve

  • cumulus cell

  • calvaria

  • body of femur

  • mesenteric lymph nodes

  • belly cord

  • endothelial cell of lymphatic vessel

  • tail of embryo

  • ankle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • membrane
  • integral component of membrane
  • rough endoplasmic reticulum
Biological process
  • protein transport
  • collagen biosynthetic process
  • protein insertion into ER membrane
  • SRP-dependent cotranslational protein targeting to membrane, translocation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9697

170829

Ensembl

ENSG00000065308

ENSMUSG00000041779

UniProt

Q15035

Q924Z5

RefSeq (mRNA)

NM_012288

NM_177409

RefSeq (protein)

NP_036420

NP_803128

Location (UCSC)Chr 6: 52.5 – 52.58 MbChr 1: 21.07 – 21.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Translocating chain-associated membrane protein 2 is a protein that in humans is encoded by the TRAM2 gene.[5][6][7]

TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065308 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041779 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  6. ^ Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM (Jan 2000). "Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene". Mamm Genome. 10 (12): 1175–8. doi:10.1007/s003359901186. PMID 10594243. S2CID 11705244.
  7. ^ a b "Entrez Gene: TRAM2 translocation associated membrane protein 2".

Further reading

  • Sudo K, Chinen K, Nakamura Y (1995). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics. 24 (2): 276–9. doi:10.1006/geno.1994.1616. PMID 7698749.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Hsu LC, Liu S, Abedinpour F, et al. (2003). "The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription". Mol. Cell. Biol. 23 (23): 8773–85. doi:10.1128/MCB.23.23.8773-8785.2003. PMC 262660. PMID 14612417.
  • Stefanovic B, Stefanovic L, Schnabl B, et al. (2004). "TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis". Mol. Cell. Biol. 24 (4): 1758–68. doi:10.1128/MCB.24.4.1758-1768.2004. PMC 344171. PMID 14749390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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