TRIM11

Protein-coding gene in the species Homo sapiens
TRIM11
Identifiers
AliasesTRIM11, BIA1, RNF92, tripartite motif containing 11
External IDsOMIM: 607868; MGI: 2137355; HomoloGene: 14225; GeneCards: TRIM11; OMA:TRIM11 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TRIM11
Genomic location for TRIM11
Band1q42.13Start228,393,673 bp[1]
End228,406,835 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TRIM11
Genomic location for TRIM11
Band11|11 B1.3Start58,868,919 bp[2]
End58,882,284 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • granulocyte

  • oocyte

  • mucosa of transverse colon

  • spleen

  • mucosa of ileum

  • blood

  • cerebellar vermis

  • monocyte
Top expressed in
  • granulocyte

  • secondary oocyte

  • spermatocyte

  • zygote

  • tibiofemoral joint

  • corneal stroma

  • thymus

  • atrium

  • primary oocyte

  • lactiferous gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ubiquitin-protein transferase activity
  • zinc ion binding
  • transcription factor binding
  • protein binding
  • protein domain specific binding
  • ubiquitin protein ligase activity
  • metal ion binding
  • transferase activity
Cellular component
  • cytoplasm
  • intracellular anatomical structure
  • nucleus
  • cytosol
Biological process
  • negative regulation of neurogenesis
  • innate immune response
  • negative regulation of transcription, DNA-templated
  • defense response to virus
  • protein ubiquitination
  • negative regulation of viral transcription
  • negative regulation of viral entry into host cell
  • positive regulation of viral entry into host cell
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81559

94091

Ensembl

ENSG00000154370

ENSMUSG00000020455

UniProt

Q96F44

Q99PQ2

RefSeq (mRNA)

NM_145214

NM_001290988
NM_053168

RefSeq (protein)

NP_660215

NP_001277917
NP_444398

Location (UCSC)Chr 1: 228.39 – 228.41 MbChr 11: 58.87 – 58.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing protein 11 is a protein found in humans that is encoded by the TRIM11 gene.[5][6]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154370 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020455 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  6. ^ a b "Entrez Gene: TRIM11 tripartite motif-containing 11".

Further reading

  • Ishikawa H, Tachikawa H, Miura Y, Takahashi N (2006). "TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system". FEBS Lett. 580 (20): 4784–92. doi:10.1016/j.febslet.2006.07.066. PMID 16904669. S2CID 33550003.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11". BMC Genet. 6: 43. doi:10.1186/1471-2156-6-43. PMC 1208879. PMID 16098226.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Niikura T, Hashimoto Y, Tajima H, et al. (2003). "A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults". Eur. J. Neurosci. 17 (6): 1150–8. doi:10.1046/j.1460-9568.2003.02553.x. PMID 12670303. S2CID 1345339.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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